Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3720039..3720838 Replicon chromosome
Accession NZ_CP079891
Organism Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag KYD87_RS18335 Protein ID WP_000347270.1
Coordinates 3720039..3720503 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag KYD87_RS18340 Protein ID WP_015953962.1
Coordinates 3720503..3720838 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYD87_RS18305 (3715041) 3715041..3715475 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KYD87_RS18310 (3715493) 3715493..3716371 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
KYD87_RS18315 (3716361) 3716361..3717140 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KYD87_RS18320 (3717151) 3717151..3717624 - 474 WP_182210630.1 PTS N-acetylgalactosamine transporter subunit IIB -
KYD87_RS18325 (3717647) 3717647..3718927 - 1281 WP_182210632.1 tagatose-bisphosphate aldolase subunit KbaZ -
KYD87_RS18330 (3719175) 3719175..3719984 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KYD87_RS18335 (3720039) 3720039..3720503 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KYD87_RS18340 (3720503) 3720503..3720838 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KYD87_RS18345 (3720987) 3720987..3722558 - 1572 WP_105284487.1 galactarate dehydratase -
KYD87_RS18350 (3723029) 3723029..3723799 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
KYD87_RS18355 (3723824) 3723824..3724714 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T210344 WP_000347270.1 NZ_CP079891:c3720503-3720039 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

>T210344 NZ_CP104503:c359674-359567 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT210344 WP_015953962.1 NZ_CP079891:c3720838-3720503 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT210344 NZ_CP104503:359730-359791 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References