Detailed information of TA system TA210337

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokA/Ldr(toxin)
• Location: 2881539..2881760
• Replicon: chromosome
• Accession: NZ_CP079891
• Organism: Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: KYD87_RS14370
• Protein ID: WP_001295224.1
• Coordinates: 2881539..2881646 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2881694..2881760 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYD87_RS14340	2876590..2876778	-	189	WP_001063310.1	cellulose biosynthesis protein BcsR	-
KYD87_RS14345	2877065..2878624	+	1560	WP_223665908.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
KYD87_RS14350	2878621..2878812	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
KYD87_RS14355	2878809..2880488	+	1680	WP_182211153.1	cellulose biosynthesis protein BcsG	-
KYD87_RS14360	2880574..2880681	-	108	WP_002431793.1	type I toxin-antitoxin system toxin Ldr family protein	-
KYD87_RS14365	2881056..2881163	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	2881212..2881275	+	64	NuclAT_15	-	-
-	2881212..2881275	+	64	NuclAT_15	-	-
-	2881212..2881275	+	64	NuclAT_15	-	-
-	2881212..2881275	+	64	NuclAT_15	-	-
-	2881212..2881275	+	64	NuclAT_17	-	-
-	2881212..2881275	+	64	NuclAT_17	-	-
-	2881212..2881275	+	64	NuclAT_17	-	-
-	2881212..2881275	+	64	NuclAT_17	-	-
-	2881212..2881275	+	64	NuclAT_19	-	-
-	2881212..2881275	+	64	NuclAT_19	-	-
-	2881212..2881275	+	64	NuclAT_19	-	-
-	2881212..2881275	+	64	NuclAT_19	-	-
-	2881212..2881275	+	64	NuclAT_21	-	-
-	2881212..2881275	+	64	NuclAT_21	-	-
-	2881212..2881275	+	64	NuclAT_21	-	-
-	2881212..2881275	+	64	NuclAT_21	-	-
-	2881212..2881277	+	66	NuclAT_10	-	-
-	2881212..2881277	+	66	NuclAT_10	-	-
-	2881212..2881277	+	66	NuclAT_10	-	-
-	2881212..2881277	+	66	NuclAT_10	-	-
-	2881212..2881277	+	66	NuclAT_12	-	-
-	2881212..2881277	+	66	NuclAT_12	-	-
-	2881212..2881277	+	66	NuclAT_12	-	-
-	2881212..2881277	+	66	NuclAT_12	-	-
KYD87_RS14370	2881539..2881646	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2881694..2881760	+	67	-	-	Antitoxin
KYD87_RS14375	2882083..2883279	+	1197	WP_223665909.1	methionine gamma-lyase	-
KYD87_RS14380	2883529..2884827	+	1299	WP_105283531.1	amino acid permease	-
KYD87_RS14385	2884843..2886054	-	1212	WP_105283532.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T210337 WP_001295224.1 NZ_CP079891:c2881646-2881539 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T210337 NZ_CP104500:4627953-4628330 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT210337 NZ_CP079891:2881694-2881760 [Escherichia fergusonii]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin