Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 24181..24787 Replicon plasmid pSYSM
Accession NC_005229
Organism Synechocystis sp. PCC 6803 (Synechocystis PCC6803)

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag SGL_RS00095 Protein ID WP_011153557.1
Coordinates 24181..24462 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SGL_RS00100 Protein ID WP_011153558.1
Coordinates 24473..24787 (+) Length 105 a.a.

Genomic Context

SGL_RS00075SGL_RS00080SGL_RS00085SGL_RS00090SGL_RS00095SGL_RS00100SGL_RS00105SGL_RS00110SGL_RS00115SGL_RS00065SGL_RS00070SGL_RS00120
Location: 21843..23219 (1377 bp)
Type: Others
Protein ID: WP_011153553.1
Location: 23255..23572 (318 bp)
Type: Others
Protein ID: WP_011153554.1
Location: 23562..23903 (342 bp)
Type: Others
Protein ID: WP_011153555.1
Location: 23890..24099 (210 bp)
Type: Others
Protein ID: WP_011153556.1
Location: 24181..24462 (282 bp)
Type: Toxin
Protein ID: WP_011153557.1
Location: 24473..24787 (315 bp)
Type: Antitoxin
Protein ID: WP_011153558.1
Location: 24798..25955 (1158 bp)
Type: Others
Protein ID: WP_011153559.1
Location: 25994..27175 (1182 bp)
Type: Others
Protein ID: WP_011153560.1
Location: 27175..27735 (561 bp)
Type: Others
Protein ID: WP_011153561.1
Location: 20523..21479 (957 bp)
Type: Others
Protein ID: WP_011153551.1
Location: 21479..21760 (282 bp)
Type: Others
Protein ID: WP_011153552.1
Location: 27859..28053 (195 bp)
Type: Others
Protein ID: WP_011153562.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SGL_RS0006520523..21479-957WP_011153551.1hypothetical protein-
SGL_RS0007021479..21760-282WP_011153552.1hypothetical protein-
SGL_RS0007521843..23219+1377WP_011153553.1hypothetical protein-
SGL_RS0008023255..23572+318WP_011153554.1nucleotidyltransferase domain-containing protein-
SGL_RS0008523562..23903+342WP_011153555.1DUF86 domain-containing protein-
SGL_RS0009023890..24099+210WP_011153556.1aminotransferase class V-fold PLP-dependent enzyme-
SGL_RS0009524181..24462+282WP_011153557.1type II toxin-antitoxin system RelE/ParE family toxinToxin
SGL_RS0010024473..24787+315WP_011153558.1HigA family addiction module antidote proteinAntitoxin
SGL_RS0010524798..25955+1158WP_011153559.1cysteine desulfurase-
SGL_RS0011025994..27175+1182WP_011153560.1AAA family ATPase-
SGL_RS0011527175..27735+561WP_011153561.1DUF4276 family protein-
SGL_RS0012027859..28053-195WP_011153562.1DUF433 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..119895119895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11075.72 Da        Isoelectric Point: 10.3094

>T21032 WP_011153557.1 NC_005229:24181-24462 [Synechocystis sp. PCC 6803]
VIRNFKDKEAQKIFERQRSRKLPGDIQQVALRKLRMLNRAETLQDLKVPPANRLEALKGDRQGQYSIRINAQWRICFQWE
NGEALDVEIIDYH

Download         Length: 282 bp

>T21032 NC_005229:24181-24462 [Synechocystis sp. PCC 6803]
GTGATTCGTAACTTTAAAGATAAAGAAGCTCAAAAAATCTTTGAACGACAACGCTCCCGCAAACTGCCTGGCGACATCCA
ACAAGTTGCCCTCAGAAAGCTCCGAATGCTAAACCGAGCCGAGACATTACAAGACCTTAAAGTTCCCCCAGCTAATCGAT
TAGAAGCTTTGAAAGGCGATCGCCAAGGACAATATAGCATTCGCATTAATGCCCAATGGCGTATCTGTTTCCAATGGGAG
AACGGAGAAGCCCTCGACGTAGAAATTATTGACTACCATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11963.85 Da        Isoelectric Point: 4.8359

>AT21032 WP_011153558.1 NC_005229:24473-24787 [Synechocystis sp. PCC 6803]
MNPDKLKPIHPGEVLLEEFLQPMNLSQNKLALAIRVPARRINEIVQGKRRITADTALRLALYFNMSPRFWLGLQMDYDLD
LAEDEIGEKLQQEVTTFNLDNVAV

Download         Length: 315 bp

>AT21032 NC_005229:24473-24787 [Synechocystis sp. PCC 6803]
ATGAATCCAGACAAACTAAAACCTATTCATCCCGGCGAAGTTCTCCTTGAAGAATTTTTGCAGCCAATGAATCTAAGCCA
AAATAAGCTAGCTTTAGCAATTCGTGTACCTGCTCGTCGTATCAACGAAATTGTGCAGGGAAAACGTCGTATTACCGCTG
ATACCGCCCTACGTTTAGCACTATATTTCAATATGTCTCCTCGGTTTTGGTTAGGCTTGCAAATGGACTATGACCTAGAT
TTAGCAGAGGATGAAATTGGCGAAAAGCTTCAACAGGAAGTAACGACTTTCAATCTAGACAACGTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References