Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 24181..24787 | Replicon | plasmid pSYSM |
Accession | NC_005229 | ||
Organism | Synechocystis sp. PCC 6803 (Synechocystis PCC6803) |
Toxin (Protein)
Gene name | graT | Uniprot ID | - |
Locus tag | SGL_RS00095 | Protein ID | WP_011153557.1 |
Coordinates | 24181..24462 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | SGL_RS00100 | Protein ID | WP_011153558.1 |
Coordinates | 24473..24787 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SGL_RS00065 | 20523..21479 | - | 957 | WP_011153551.1 | hypothetical protein | - |
SGL_RS00070 | 21479..21760 | - | 282 | WP_011153552.1 | hypothetical protein | - |
SGL_RS00075 | 21843..23219 | + | 1377 | WP_011153553.1 | hypothetical protein | - |
SGL_RS00080 | 23255..23572 | + | 318 | WP_011153554.1 | nucleotidyltransferase domain-containing protein | - |
SGL_RS00085 | 23562..23903 | + | 342 | WP_011153555.1 | DUF86 domain-containing protein | - |
SGL_RS00090 | 23890..24099 | + | 210 | WP_011153556.1 | aminotransferase class V-fold PLP-dependent enzyme | - |
SGL_RS00095 | 24181..24462 | + | 282 | WP_011153557.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
SGL_RS00100 | 24473..24787 | + | 315 | WP_011153558.1 | HigA family addiction module antidote protein | Antitoxin |
SGL_RS00105 | 24798..25955 | + | 1158 | WP_011153559.1 | cysteine desulfurase | - |
SGL_RS00110 | 25994..27175 | + | 1182 | WP_011153560.1 | AAA family ATPase | - |
SGL_RS00115 | 27175..27735 | + | 561 | WP_011153561.1 | DUF4276 family protein | - |
SGL_RS00120 | 27859..28053 | - | 195 | WP_011153562.1 | DUF433 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..119895 | 119895 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11075.72 Da Isoelectric Point: 10.3094
>T21032 WP_011153557.1 NC_005229:24181-24462 [Synechocystis sp. PCC 6803]
VIRNFKDKEAQKIFERQRSRKLPGDIQQVALRKLRMLNRAETLQDLKVPPANRLEALKGDRQGQYSIRINAQWRICFQWE
NGEALDVEIIDYH
VIRNFKDKEAQKIFERQRSRKLPGDIQQVALRKLRMLNRAETLQDLKVPPANRLEALKGDRQGQYSIRINAQWRICFQWE
NGEALDVEIIDYH
Download Length: 282 bp
>T21032 NC_005229:24181-24462 [Synechocystis sp. PCC 6803]
GTGATTCGTAACTTTAAAGATAAAGAAGCTCAAAAAATCTTTGAACGACAACGCTCCCGCAAACTGCCTGGCGACATCCA
ACAAGTTGCCCTCAGAAAGCTCCGAATGCTAAACCGAGCCGAGACATTACAAGACCTTAAAGTTCCCCCAGCTAATCGAT
TAGAAGCTTTGAAAGGCGATCGCCAAGGACAATATAGCATTCGCATTAATGCCCAATGGCGTATCTGTTTCCAATGGGAG
AACGGAGAAGCCCTCGACGTAGAAATTATTGACTACCATTAA
GTGATTCGTAACTTTAAAGATAAAGAAGCTCAAAAAATCTTTGAACGACAACGCTCCCGCAAACTGCCTGGCGACATCCA
ACAAGTTGCCCTCAGAAAGCTCCGAATGCTAAACCGAGCCGAGACATTACAAGACCTTAAAGTTCCCCCAGCTAATCGAT
TAGAAGCTTTGAAAGGCGATCGCCAAGGACAATATAGCATTCGCATTAATGCCCAATGGCGTATCTGTTTCCAATGGGAG
AACGGAGAAGCCCTCGACGTAGAAATTATTGACTACCATTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11963.85 Da Isoelectric Point: 4.8359
>AT21032 WP_011153558.1 NC_005229:24473-24787 [Synechocystis sp. PCC 6803]
MNPDKLKPIHPGEVLLEEFLQPMNLSQNKLALAIRVPARRINEIVQGKRRITADTALRLALYFNMSPRFWLGLQMDYDLD
LAEDEIGEKLQQEVTTFNLDNVAV
MNPDKLKPIHPGEVLLEEFLQPMNLSQNKLALAIRVPARRINEIVQGKRRITADTALRLALYFNMSPRFWLGLQMDYDLD
LAEDEIGEKLQQEVTTFNLDNVAV
Download Length: 315 bp
>AT21032 NC_005229:24473-24787 [Synechocystis sp. PCC 6803]
ATGAATCCAGACAAACTAAAACCTATTCATCCCGGCGAAGTTCTCCTTGAAGAATTTTTGCAGCCAATGAATCTAAGCCA
AAATAAGCTAGCTTTAGCAATTCGTGTACCTGCTCGTCGTATCAACGAAATTGTGCAGGGAAAACGTCGTATTACCGCTG
ATACCGCCCTACGTTTAGCACTATATTTCAATATGTCTCCTCGGTTTTGGTTAGGCTTGCAAATGGACTATGACCTAGAT
TTAGCAGAGGATGAAATTGGCGAAAAGCTTCAACAGGAAGTAACGACTTTCAATCTAGACAACGTTGCCGTTTAA
ATGAATCCAGACAAACTAAAACCTATTCATCCCGGCGAAGTTCTCCTTGAAGAATTTTTGCAGCCAATGAATCTAAGCCA
AAATAAGCTAGCTTTAGCAATTCGTGTACCTGCTCGTCGTATCAACGAAATTGTGCAGGGAAAACGTCGTATTACCGCTG
ATACCGCCCTACGTTTAGCACTATATTTCAATATGTCTCCTCGGTTTTGGTTAGGCTTGCAAATGGACTATGACCTAGAT
TTAGCAGAGGATGAAATTGGCGAAAAGCTTCAACAGGAAGTAACGACTTTCAATCTAGACAACGTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|