Detailed information of TA system TA210310

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4480628..4480885
• Replicon: chromosome
• Accession: NZ_CP079884
• Organism: Escherichia fergusonii strain 6S41-1

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: KYC43_RS21895
• Protein ID: WP_001135731.1
• Coordinates: 4480628..4480780 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4480837..4480885 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYC43_RS21865	4476492..4477202	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
KYC43_RS21870	4477640..4479010	+	1371	WP_000184983.1	MFS transporter	-
KYC43_RS21875	4479260..4479550	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
KYC43_RS21880	4479832..4480044	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
KYC43_RS21885	4480098..4480469	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
KYC43_RS21890	4480580..4480651	+	72	WP_216665726.1	hypothetical protein	-
KYC43_RS21895	4480628..4480780	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4480837..4480885	+	49	-	-	Antitoxin
KYC43_RS21900	4481080..4481439	-	360	WP_141095883.1	hypothetical protein	-
KYC43_RS21905	4481508..4483577	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
KYC43_RS21910	4483587..4484498	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
KYC43_RS21915	4484594..4484893	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T210310 WP_001135731.1 NZ_CP079884:c4480780-4480628 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T210310 NZ_CP104494:c3089322-3088909 [Ralstonia pseudosolanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin

Nucleotide

• Length: 49 bp

>AT210310 NZ_CP079884:4480837-4480885 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin