Detailed information of TA system TA210292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2710528..2710753
• Replicon: chromosome
• Accession: NZ_CP079884
• Organism: Escherichia fergusonii strain 6S41-1

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: KYC43_RS13175
• Protein ID: WP_000813255.1
• Coordinates: 2710528..2710683 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2710695..2710753 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYC43_RS13120	2705774..2706049	-	276	WP_000950569.1	phage holin family protein	-
KYC43_RS13125	2706039..2706431	-	393	WP_001384627.1	putative holin	-
KYC43_RS13150	2707593..2708282	-	690	WP_001546004.1	bacteriophage antitermination protein Q	-
KYC43_RS13155	2708279..2708638	-	360	WP_044502258.1	RusA family crossover junction endodeoxyribonuclease	-
KYC43_RS13160	2708651..2709700	-	1050	WP_044502259.1	DUF968 domain-containing protein	-
KYC43_RS13165	2709702..2709980	-	279	WP_001360223.1	hypothetical protein	-
KYC43_RS13170	2710047..2710310	-	264	WP_000975572.1	hypothetical protein	-
KYC43_RS13175	2710528..2710683	-	156	WP_000813255.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2710695..2710753	+	59	-	-	Antitoxin
KYC43_RS13180	2711588..2712178	-	591	WP_039005580.1	RloB family protein	-
KYC43_RS13185	2712206..2713519	-	1314	WP_039005582.1	ATP-binding protein	-
KYC43_RS13190	2714017..2714202	-	186	Protein_2578	hypothetical protein	-
KYC43_RS13195	2714238..2714699	-	462	WP_244469380.1	replication protein P	-
KYC43_RS13200	2714692..2715729	-	1038	WP_039005584.1	DnaT-like ssDNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2681319..2727808	46489

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5726.85 Da
• Isoelectric Point: 6.1531

>T210292 WP_000813255.1 NZ_CP079884:c2710683-2710528 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYESEE

Nucleotide

• Length: 156 bp

>T210292 NZ_CP104488:c4110429-4110145 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT210292 NZ_CP079884:2710695-2710753 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin