Detailed information of TA system TA210276

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 672764..673022
• Replicon: chromosome
• Accession: NZ_CP079884
• Organism: Escherichia fergusonii strain 6S41-1

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: KYC43_RS03295
• Protein ID: WP_046082123.1
• Coordinates: 672764..672916 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	672965..673022 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYC43_RS03275	667829..668416	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
KYC43_RS03280	668450..669016	-	567	WP_000528529.1	acetate uptake transporter	-
KYC43_RS03285	669524..671440	+	1917	WP_000516135.1	molecular chaperone DnaK	-
KYC43_RS03290	671529..672659	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
KYC43_RS03295	672764..672916	-	153	WP_046082123.1	type I toxin-antitoxin system toxin MokC	Toxin
-	672965..673022	+	58	-	-	Antitoxin
KYC43_RS03300	673091..673255	-	165	WP_223671943.1	hypothetical protein	-
KYC43_RS03305	673456..674622	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
KYC43_RS03310	674690..675589	+	900	WP_000019049.1	transcriptional activator NhaR	-
KYC43_RS03315	675685..675948	-	264	WP_001274021.1	30S ribosomal protein S20	-
KYC43_RS03320	676051..676269	+	219	WP_012599853.1	DUF2575 family protein	-
KYC43_RS03325	676277..677218	+	942	WP_000767324.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5511.59 Da
• Isoelectric Point: 7.1312

>T210276 WP_046082123.1 NZ_CP079884:c672916-672764 [Escherichia fergusonii]
MKQHKAIIVALIVICITAVVVALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T210276 NZ_CP104484:2442027-2442311 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT210276 NZ_CP079884:672965-673022 [Escherichia fergusonii]
GTTCTGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin