Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 543230..544029 Replicon chromosome
Accession NZ_CP079884
Organism Escherichia fergusonii strain 6S41-1

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag KYC43_RS02570 Protein ID WP_000347270.1
Coordinates 543230..543694 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag KYC43_RS02575 Protein ID WP_015953962.1
Coordinates 543694..544029 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYC43_RS02540 (538232) 538232..538666 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KYC43_RS02545 (538684) 538684..539562 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
KYC43_RS02550 (539552) 539552..540331 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KYC43_RS02555 (540342) 540342..540815 - 474 WP_182210630.1 PTS N-acetylgalactosamine transporter subunit IIB -
KYC43_RS02560 (540838) 540838..542118 - 1281 WP_182210632.1 tagatose-bisphosphate aldolase subunit KbaZ -
KYC43_RS02565 (542366) 542366..543175 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KYC43_RS02570 (543230) 543230..543694 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KYC43_RS02575 (543694) 543694..544029 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KYC43_RS02580 (544178) 544178..545749 - 1572 WP_105284487.1 galactarate dehydratase -
KYC43_RS02585 (546220) 546220..546990 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
KYC43_RS02590 (547015) 547015..547905 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T210275 WP_000347270.1 NZ_CP079884:c543694-543230 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

>T210275 NZ_CP104484:2100704-2100807 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT210275 WP_015953962.1 NZ_CP079884:c544029-543694 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT210275 NZ_CP104484:c2100809-2100664 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References