Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3888246..3888748 Replicon chromosome
Accession NZ_CP079882
Organism Proteus terrae strain 20Q172tw

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KZA80_RS18145 Protein ID WP_075671248.1
Coordinates 3888494..3888748 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KZA80_RS18140 Protein ID WP_072068851.1
Coordinates 3888246..3888497 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZA80_RS18115 (KZA80_18075) 3883837..3884613 + 777 WP_006534565.1 phosphate ABC transporter ATP-binding protein PstB -
KZA80_RS18120 (KZA80_18080) 3884628..3885362 + 735 WP_075671254.1 phosphate signaling complex protein PhoU -
KZA80_RS18125 (KZA80_18085) 3885578..3886417 + 840 WP_036933789.1 ABC transporter substrate-binding protein -
KZA80_RS18130 (KZA80_18090) 3886524..3887261 + 738 WP_075671252.1 amino acid ABC transporter permease -
KZA80_RS18135 (KZA80_18095) 3887263..3888015 + 753 WP_075671250.1 amino acid ABC transporter permease -
KZA80_RS18140 (KZA80_18100) 3888246..3888497 + 252 WP_072068851.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KZA80_RS18145 (KZA80_18105) 3888494..3888748 + 255 WP_075671248.1 Txe/YoeB family addiction module toxin Toxin
KZA80_RS18150 (KZA80_18110) 3888905..3890263 + 1359 WP_075671246.1 NCS2 family permease -
KZA80_RS18155 (KZA80_18115) 3890344..3890655 + 312 WP_098941657.1 monooxygenase -
KZA80_RS18160 (KZA80_18120) 3890705..3891253 - 549 WP_252447048.1 GNAT family protein -
KZA80_RS18165 (KZA80_18125) 3891256..3892728 - 1473 WP_075671240.1 glycosyltransferase family 39 protein -
KZA80_RS18170 (KZA80_18130) 3892917..3893414 + 498 WP_075671238.1 Der GTPase-activating protein YihI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.78 Da        Isoelectric Point: 9.9411

>T210273 WP_075671248.1 NZ_CP079882:3888494-3888748 [Proteus terrae]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Download         Length: 255 bp

>T210273 NZ_CP104484:881304-881702 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.77 Da        Isoelectric Point: 4.4354

>AT210273 WP_072068851.1 NZ_CP079882:3888246-3888497 [Proteus terrae]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Download         Length: 252 bp

>AT210273 NZ_CP104484:881077-881304 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References