Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2026832..2027442 Replicon chromosome
Accession NZ_CP079863
Organism Mycobacterium sp. SMC-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KXD96_RS09625 Protein ID WP_260745297.1
Coordinates 2027161..2027442 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KXD96_RS09620 Protein ID WP_260744355.1
Coordinates 2026832..2027161 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD96_RS09585 (KXD96_09490) 2022445..2023173 + 729 WP_260744350.1 alpha/beta hydrolase -
KXD96_RS09590 (KXD96_09495) 2023300..2023935 + 636 WP_260745296.1 HD domain-containing protein -
KXD96_RS09595 (KXD96_09500) 2023953..2024636 + 684 WP_260744351.1 nitroreductase family protein -
KXD96_RS09600 (KXD96_09505) 2024633..2025169 + 537 WP_260744352.1 cupin domain-containing protein -
KXD96_RS09610 (KXD96_09515) 2025618..2025941 + 324 WP_260744353.1 hypothetical protein -
KXD96_RS09615 (KXD96_09520) 2026005..2026835 + 831 WP_260744354.1 hypothetical protein -
KXD96_RS09620 (KXD96_09525) 2026832..2027161 - 330 WP_260744355.1 helix-turn-helix transcriptional regulator Antitoxin
KXD96_RS09625 (KXD96_09530) 2027161..2027442 - 282 WP_260745297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXD96_RS09630 (KXD96_09535) 2027526..2028884 - 1359 WP_260744356.1 site-specific integrase -
KXD96_RS09635 (KXD96_09540) 2028884..2029063 - 180 WP_244275375.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(3-84)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10199.73 Da        Isoelectric Point: 8.6800

>T210259 WP_260745297.1 NZ_CP079863:c2027442-2027161 [Mycobacterium sp. SMC-2]
MAAVAGAIDLLEPEGPTLGRPIVDKVNGSKFHSMKELRPAGTSIRVLFIFDPARQAILLLGGNKAGDWKRWYDRNIPIAD
ARFESWLATEHGG

Download         Length: 282 bp

>T210259 NZ_CP104482:841258-841671 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11716.18 Da        Isoelectric Point: 6.2270

>AT210259 WP_260744355.1 NZ_CP079863:c2027161-2026832 [Mycobacterium sp. SMC-2]
MTMARNWRDIRADAIAQGALDTNRASAAREEMREAVQAHRLAEIRKALGHSRQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGQLRVVAEFGDDTVELTA

Download         Length: 330 bp

>AT210259 NZ_CP104482:841011-841277 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References