Detailed information of TA system TA210258

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 6705978..6706630
• Replicon: chromosome
• Accession: NZ_CP079862
• Organism: Frankia sp. ArI3

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: KZA76_RS27800
• Protein ID: WP_044887977.1
• Coordinates: 6705978..6706301 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KZA76_RS27805
• Protein ID: WP_044887967.1
• Coordinates: 6706298..6706630 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZA76_RS33070	6701805..6702608	+	804	WP_255649276.1	TIR domain-containing protein	-
KZA76_RS33075	6703295..6704986	+	1692	WP_255650256.1	tetratricopeptide repeat protein	-
KZA76_RS27795	6705010..6705519	-	510	WP_128423397.1	hypothetical protein	-
KZA76_RS27800	6705978..6706301	+	324	WP_044887977.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZA76_RS27805	6706298..6706630	+	333	WP_044887967.1	helix-turn-helix transcriptional regulator	Antitoxin
KZA76_RS27810	6706956..6708356	+	1401	WP_255649277.1	ATP-binding protein	-
KZA76_RS33080	6709312..6709701	+	390	Protein_5659	glycosyltransferase family 39 protein	-
KZA76_RS33085	6709855..6710049	+	195	Protein_5660	hypothetical protein	-
KZA76_RS27820	6711277..6711588	+	312	WP_128423396.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (7-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-97)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11851.43 Da
• Isoelectric Point: 6.0799

>T210258 WP_044887977.1 NZ_CP079862:6705978-6706301 [Frankia sp. ArI3]
MCRTDSASADLVAEAIDMLAEHGPGLGRPLVDRLTGSTYHHMKELRPGSAGATEIRLIFAFDPRREAVFLVAGDKSGVWR
TWYQTAVPLADERFGEHLRILKEQEGS

Nucleotide

• Length: 324 bp

>T210258 NZ_CP104482:370303-370578 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11894.49 Da
• Isoelectric Point: 11.5412

>AT210258 WP_044887967.1 NZ_CP079862:6706298-6706630 [Frankia sp. ArI3]
MTTPSNWRDVKARARATDPRWDSAARTARRAEMRSQMLASVSGAQLAEIRNQLGLTQAQLAEATGLTQARISQIENGTAT
GLEVLRTYITGLGGHLDIVARIGNIHLNIA

Nucleotide

• Length: 333 bp

>AT210258 NZ_CP104482:370040-370300 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA