Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5428421..5429124 Replicon chromosome
Accession NZ_CP079862
Organism Frankia sp. ArI3

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag KZA76_RS22330 Protein ID WP_044887373.1
Coordinates 5428753..5429124 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZA76_RS22325 Protein ID WP_044887374.1
Coordinates 5428421..5428756 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZA76_RS22310 5426478..5426789 + 312 WP_242422789.1 hypothetical protein -
KZA76_RS22315 5426816..5427061 + 246 WP_044887376.1 hypothetical protein -
KZA76_RS22320 5427058..5427459 + 402 WP_044887375.1 type II toxin-antitoxin system VapC family toxin -
KZA76_RS22325 5428421..5428756 - 336 WP_044887374.1 helix-turn-helix transcriptional regulator Antitoxin
KZA76_RS22330 5428753..5429124 - 372 WP_044887373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZA76_RS22335 5429643..5430863 + 1221 WP_052681379.1 toll/interleukin-1 receptor domain-containing protein -
KZA76_RS22340 5430994..5432097 + 1104 WP_044887372.1 TAXI family TRAP transporter solute-binding subunit -
KZA76_RS22345 5432277..5432468 + 192 WP_052681378.1 hypothetical protein -
KZA76_RS32565 5432599..5432976 - 378 WP_255650242.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13671.37 Da        Isoelectric Point: 4.3800

>T210256 WP_044887373.1 NZ_CP079862:c5429124-5428753 [Frankia sp. ArI3]
VDEWEVRVTDEFLAWVDGLDPRSKALVVDAIDRLADAGPGLGRPLVDRLVGSEIHNLKELRPGSAGSSEIRVLFVFDPWR
CAILLVGGDKSGDWSGWYRTAIPRAETLYVEYVKEREAEEGSS

Download         Length: 372 bp

>T210256 NZ_CP104480:c43060-42779 [Salmonella enterica]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12217.74 Da        Isoelectric Point: 7.3188

>AT210256 WP_044887374.1 NZ_CP079862:c5428756-5428421 [Frankia sp. ArI3]
MTRFPRWNDVRAGLVADAGGEEALAEAHRRNQAYIDGHRLADRRRLLGLTQTDVAEHMGVSKSRVSQIERGEVSTVDVIA
RYVRALGGQLQITAVFGDDLYILRGTDTPAA

Download         Length: 336 bp

>AT210256 NZ_CP104480:c43301-43050 [Salmonella enterica]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References