Detailed information of TA system TA210246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 1979332..1979852
• Replicon: chromosome
• Accession: NZ_CP079855
• Organism: Agrobacterium fabrum strain LBA645

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A9CID9
• Locus tag: KXJ62_RS09845
• Protein ID: WP_010972002.1
• Coordinates: 1979332..1979601 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q7CY23
• Locus tag: KXJ62_RS09850
• Protein ID: WP_010972003.1
• Coordinates: 1979598..1979852 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ62_RS09825 (KXJ62_09820)	1974363..1976057	-	1695	WP_010971998.1	iron ABC transporter permease	-
KXJ62_RS09830 (KXJ62_09825)	1976067..1977050	-	984	WP_010971999.1	ABC transporter substrate-binding protein	-
KXJ62_RS09835 (KXJ62_09830)	1977359..1978603	-	1245	WP_010972000.1	PLP-dependent aminotransferase family protein	-
KXJ62_RS09840 (KXJ62_09835)	1978878..1979327	+	450	WP_010972001.1	RbsD/FucU family protein	-
KXJ62_RS09845 (KXJ62_09840)	1979332..1979601	-	270	WP_010972002.1	Txe/YoeB family addiction module toxin	Toxin
KXJ62_RS09850 (KXJ62_09845)	1979598..1979852	-	255	WP_010972003.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KXJ62_RS09855 (KXJ62_09850)	1979991..1981010	-	1020	WP_010972004.1	ketol-acid reductoisomerase	-
KXJ62_RS09860 (KXJ62_09855)	1981058..1981711	-	654	WP_006311841.1	TetR/AcrR family transcriptional regulator	-
KXJ62_RS09865 (KXJ62_09860)	1982111..1983016	-	906	WP_010972005.1	AraC family transcriptional regulator	-
KXJ62_RS09870 (KXJ62_09865)	1983206..1984252	+	1047	WP_006311839.1	NAD(P)-dependent alcohol dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10612.09 Da
• Isoelectric Point: 9.8742

>T210246 WP_010972002.1 NZ_CP079855:c1979601-1979332 [Agrobacterium fabrum]
MKLVWTLSSWDDYEFWQRTDARMVEKINDLIRNAKRTPFAGLGKPEPLKGDMAGYWSRRITAEHRFVYRVSGSGSEQRLE
VIQCRFHYQ

Nucleotide

• Length: 270 bp

>T210246 NZ_CP104479:c1034976-1034449 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9577.70 Da
• Isoelectric Point: 4.6749

>AT210246 WP_010972003.1 NZ_CP079855:c1979852-1979598 [Agrobacterium fabrum]
MANVRFTEFRQNFATHFDRVLETRAPLLVTRQGKEAVVVLAEGEYESMQETLHLLSNPANASRLRASMGELERGDTIERD
PTEE

Nucleotide

• Length: 255 bp

>AT210246 NZ_CP104479:c1035263-1034973 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• PDB: 6N90

Antitoxin

• AlphaFold DB: Q7CY23