Detailed information of TA system TA210241

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4308989..4309214
• Replicon: chromosome
• Accession: NZ_CP079839
• Organism: Salmonella enterica strain LHICA_E3

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: A0A636EVM3
• Locus tag: JMJ87_RS20965
• Protein ID: WP_001597144.1
• Coordinates: 4308989..4309144 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4309156..4309214 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ87_RS20930	4304474..4305013	-	540	WP_079809894.1	lysozyme	-
JMJ87_RS20935	4304991..4305299	-	309	WP_000177624.1	HP1 family phage holin	-
JMJ87_RS20940	4305397..4306788	-	1392	WP_031571465.1	ATP-binding protein	-
JMJ87_RS20945	4306931..4307509	-	579	WP_079809895.1	DUF1133 family protein	-
JMJ87_RS20950	4307506..4307787	-	282	WP_057519936.1	DUF1364 family protein	-
JMJ87_RS24945	4307784..4307978	-	195	WP_072142230.1	hypothetical protein	-
JMJ87_RS20955	4307975..4308412	-	438	WP_079809896.1	recombination protein NinB	-
JMJ87_RS24950	4308442..4308522	-	81	Protein_4100	hypothetical protein	-
JMJ87_RS20960	4308583..4308750	-	168	WP_175441067.1	hypothetical protein	-
JMJ87_RS20965	4308989..4309144	-	156	WP_001597144.1	Hok/Gef family protein	Toxin
-	4309156..4309214	+	59	-	-	Antitoxin
JMJ87_RS20970	4309347..4309619	-	273	WP_000687976.1	hypothetical protein	-
JMJ87_RS20975	4309616..4310011	-	396	WP_047588288.1	DUF977 family protein	-
JMJ87_RS20980	4310029..4310781	-	753	WP_219165083.1	ATP-binding protein	-
JMJ87_RS20985	4310788..4311656	-	869	Protein_4106	DNA-binding protein	-
JMJ87_RS20990	4311701..4312195	-	495	WP_219165085.1	hypothetical protein	-
JMJ87_RS20995	4312192..4312452	-	261	WP_072104698.1	YdaS family helix-turn-helix protein	-
JMJ87_RS21000	4312556..4312942	+	387	WP_052938955.1	helix-turn-helix domain-containing protein	-
JMJ87_RS21005	4313108..4313263	+	156	WP_071992601.1	DUF1391 family protein	-
JMJ87_RS21010	4313565..4313762	-	198	WP_219165087.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4271617..4321891	50274

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5742.91 Da
• Isoelectric Point: 6.1531

>T210241 WP_001597144.1 NZ_CP079839:c4309144-4308989 [Salmonella enterica]
MKQQKAMLIALIVICITVVMAVLVTRKDLCEVRIRTGQTEVAVFTAYESEE

Nucleotide

• Length: 156 bp

>T210241 NZ_CP104479:c90448-90128 [Salmonella enterica]
ATGAATACTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGCAAATGTTACTGAC
AAGCCTGCTAGACCAGCACTATGGTCTCACGCTAAACGACACGCCATTCAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCCGATGCCGTAAACTTTCTGGTTGAACGCTATGAGCTAGTTCGTATTGACCAAAAAGGCTTC
TCTGTGCAAGATCAAGAACCTTGGTTAACTTCTATGGATGTCCACCGAGCACGATTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin

Nucleotide

• Length: 59 bp

>AT210241 NZ_CP079839:4309156-4309214 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A636EVM3

Antitoxin