Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4542274..4542876 Replicon chromosome
Accession NZ_CP079837
Organism Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMJ84_RS21690 Protein ID WP_079790896.1
Coordinates 4542565..4542876 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMJ84_RS21685 Protein ID WP_141133547.1
Coordinates 4542274..4542564 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ84_RS21670 (4539760) 4539760..4540662 + 903 WP_058115027.1 formate dehydrogenase subunit beta -
JMJ84_RS21675 (4540659) 4540659..4541294 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
JMJ84_RS21680 (4541291) 4541291..4542220 + 930 WP_219141412.1 formate dehydrogenase accessory protein FdhE -
JMJ84_RS21685 (4542274) 4542274..4542564 - 291 WP_141133547.1 helix-turn-helix domain-containing protein Antitoxin
JMJ84_RS21690 (4542565) 4542565..4542876 - 312 WP_079790896.1 toxin HigB-2 Toxin
JMJ84_RS21695 (4543107) 4543107..4543495 + 389 Protein_4261 hypothetical protein -
JMJ84_RS21700 (4543504) 4543504..4544445 - 942 WP_024134888.1 fatty acid biosynthesis protein FabY -
JMJ84_RS21705 (4544490) 4544490..4544927 - 438 WP_079790898.1 D-aminoacyl-tRNA deacylase -
JMJ84_RS21710 (4544924) 4544924..4545796 - 873 WP_000921423.1 virulence factor BrkB family protein -
JMJ84_RS21715 (4545790) 4545790..4546389 - 600 WP_000965699.1 glucose-1-phosphatase -
JMJ84_RS21720 (4546580) 4546580..4547383 - 804 WP_000059685.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12201.13 Da        Isoelectric Point: 9.4357

>T210206 WP_079790896.1 NZ_CP079837:c4542876-4542565 [Salmonella enterica subsp. salamae]
MIFIETEIFTEDVKDLLDDDEYHRLQLFLAVQPESGDLIQDSGGLRKIRWGVRGRGKRSGVRIIYFYRASRSEIRLLLIY
KKGLKDDLTVQEKAVLRMLNERW

Download         Length: 312 bp

>T210206 NZ_CP104472:c853572-853318 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10594.16 Da        Isoelectric Point: 9.1188

>AT210206 WP_141133547.1 NZ_CP079837:c4542564-4542274 [Salmonella enterica subsp. salamae]
MDKALFERLTKSMTQMNEIVEGGGQPSRTFYIDAMKIKEIRQASGLSQTKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPEHVISALGC

Download         Length: 291 bp

>AT210206 NZ_CP104472:c853820-853569 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References