Detailed information of TA system TA210204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4235026..4235686
• Replicon: chromosome
• Accession: NZ_CP079837
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JMJ84_RS20300
• Protein ID: WP_219141339.1
• Coordinates: 4235333..4235686 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JMJ84_RS20295
• Protein ID: WP_079790643.1
• Coordinates: 4235026..4235328 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ84_RS20280 (4230205)	4230205..4231239	-	1035	WP_257590035.1	ParA family protein	-
JMJ84_RS20285 (4231534)	4231534..4232793	+	1260	WP_219141337.1	integrase arm-type DNA-binding domain-containing protein	-
JMJ84_RS20290 (4233661)	4233661..4234545	-	885	WP_219141338.1	integrase domain-containing protein	-
JMJ84_RS20295 (4235026)	4235026..4235328	-	303	WP_079790643.1	XRE family transcriptional regulator	Antitoxin
JMJ84_RS20300 (4235333)	4235333..4235686	-	354	WP_219141339.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMJ84_RS20305 (4236165)	4236165..4236386	-	222	WP_219141340.1	helix-turn-helix transcriptional regulator	-
JMJ84_RS20310 (4236383)	4236383..4236844	-	462	WP_219141341.1	hypothetical protein	-
JMJ84_RS23150 (4237391)	4237391..4240474	+	3084	WP_257590036.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13465.29 Da
• Isoelectric Point: 9.5699

>T210204 WP_219141339.1 NZ_CP079837:c4235686-4235333 [Salmonella enterica subsp. salamae]
VWTIKTTDTFDRWFTSLNDTDRASALAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Nucleotide

• Length: 354 bp

>T210204 NZ_CP104472:c366508-366221 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11070.90 Da
• Isoelectric Point: 5.7316

>AT210204 WP_079790643.1 NZ_CP079837:c4235328-4235026 [Salmonella enterica subsp. salamae]
MGRTLEQLIADEKPEVVAEAQAMAMDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT210204 NZ_CP104472:c366747-366508 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA