Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3276145..3276647 Replicon chromosome
Accession NZ_CP079837
Organism Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JMJ84_RS15665 Protein ID WP_219141044.1
Coordinates 3276145..3276399 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JMJ84_RS15670 Protein ID WP_079788993.1
Coordinates 3276396..3276647 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ84_RS15650 (3271982) 3271982..3274237 + 2256 WP_079808911.1 TonB-dependent siderophore receptor -
JMJ84_RS15655 (3274285) 3274285..3274990 + 706 Protein_3080 enterobactin synthase subunit EntD -
JMJ84_RS15660 (3275002) 3275002..3276120 + 1119 WP_219141043.1 YbdK family carboxylate-amine ligase -
JMJ84_RS15665 (3276145) 3276145..3276399 - 255 WP_219141044.1 Txe/YoeB family addiction module toxin Toxin
JMJ84_RS15670 (3276396) 3276396..3276647 - 252 WP_079788993.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMJ84_RS15675 (3276829) 3276829..3277077 + 249 WP_000682497.1 DUF1158 family protein -
JMJ84_RS15680 (3277083) 3277083..3277424 - 342 WP_000155633.1 RamA family antibiotic efflux transcriptional regulator -
JMJ84_RS15685 (3277714) 3277714..3278295 + 582 WP_000113612.1 TetR/AcrR family transcriptional regulator -
JMJ84_RS15690 (3278295) 3278295..3278663 + 369 WP_000348992.1 MmcQ/YjbR family DNA-binding protein -
JMJ84_RS15695 (3278760) 3278760..3279413 + 654 WP_219141045.1 oxygen-insensitive NAD(P)H nitroreductase -
JMJ84_RS15700 (3279613) 3279613..3279741 + 129 Protein_3089 PTS mannose transporter subunit IIAB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10205.67 Da        Isoelectric Point: 8.0024

>T210201 WP_219141044.1 NZ_CP079837:c3276399-3276145 [Salmonella enterica subsp. salamae]
VKLTWSEEAWEDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKYNLSGFWSRRITEEHRLVYALTDDALLIAAC
RYHY

Download         Length: 255 bp

>T210201 NZ_CP104471:c4562087-4561716 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACAGCAGCCGTGATGGGCGCTTTTGAAATTATAGATGTATCTCGGGATATCGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATCCTGGCCACAGCGCAGAGCAGAAAATGTCCCTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTTCTTACGCCTTACCAGCTGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.59 Da        Isoelectric Point: 4.8090

>AT210201 WP_079788993.1 NZ_CP079837:c3276647-3276396 [Salmonella enterica subsp. salamae]
MRTISYSEARQNLSATMVKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIESLKSGRGVEKD
IIE

Download         Length: 252 bp

>AT210201 NZ_CP104471:c4562332-4562090 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAGCCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References