Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1366013..1366518 Replicon chromosome
Accession NZ_CP079837
Organism Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A5H6P158
Locus tag JMJ84_RS06400 Protein ID WP_023218457.1
Coordinates 1366013..1366273 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5H6P2W8
Locus tag JMJ84_RS06405 Protein ID WP_052932205.1
Coordinates 1366273..1366518 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ84_RS06385 (1361215) 1361215..1363221 + 2007 WP_219141798.1 two-component system sensor histidine kinase PgtB -
JMJ84_RS06390 (1363211) 1363211..1364458 + 1248 WP_219142371.1 two-component system response regulator PgtA -
JMJ84_RS06395 (1364726) 1364726..1365664 + 939 WP_111770589.1 omptin family outer membrane protease PgtE -
JMJ84_RS06400 (1366013) 1366013..1366273 - 261 WP_023218457.1 Txe/YoeB family addiction module toxin Toxin
JMJ84_RS06405 (1366273) 1366273..1366518 - 246 WP_052932205.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JMJ84_RS06410 (1366929) 1366929..1367288 - 360 WP_219141799.1 hypothetical protein -
JMJ84_RS06415 (1367538) 1367538..1367801 + 264 WP_072157349.1 ogr/Delta-like zinc finger family protein -
JMJ84_RS06420 (1367877) 1367877..1368701 - 825 WP_219141800.1 integrase arm-type DNA-binding domain-containing protein -
JMJ84_RS06430 (1369029) 1369029..1369970 - 942 WP_219141801.1 formate/nitrite transporter family protein -
JMJ84_RS06435 (1370260) 1370260..1371015 + 756 WP_000776789.1 phospholipid-binding lipoprotein MlaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - pla 1357881..1368701 10820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10202.88 Da        Isoelectric Point: 10.2570

>T210191 WP_023218457.1 NZ_CP079837:c1366273-1366013 [Salmonella enterica subsp. salamae]
MKVRISPQAKSDLQYWAETDPKTHNKVMELIKSAKESPFKGIGKPEALKHRKPLWSRRITKEHRLVYYVEQGDLYIVACR
YHYTTI

Download         Length: 261 bp

>T210191 NZ_CP104471:c304494-304207 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9036.05 Da        Isoelectric Point: 4.4180

>AT210191 WP_052932205.1 NZ_CP079837:c1366518-1366273 [Salmonella enterica subsp. salamae]
MQHVNYTDARQHLADLMQQANDDRAPILVTRKGAKSVVMIDAEEFASIQETLHLFSNPANAAHIEASLASLERGDYEELD
I

Download         Length: 246 bp

>AT210191 NZ_CP104471:c304803-304501 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
CTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCTGTGGGAGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6P158

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6P2W8

References