Detailed information of TA system TA210174

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2089076..2089301
• Replicon: chromosome
• Accession: NZ_CP079836
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA1

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: A0A636EVM3
• Locus tag: JMJ86_RS09990
• Protein ID: WP_001597144.1
• Coordinates: 2089146..2089301 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2089076..2089134 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ86_RS24570	2084690..2084920	-	231	WP_058111753.1	hypothetical protein	-
JMJ86_RS09950	2085026..2085181	-	156	WP_071992601.1	DUF1391 family protein	-
JMJ86_RS09955	2085347..2085733	-	387	WP_052938955.1	helix-turn-helix domain-containing protein	-
JMJ86_RS09960	2085837..2086097	+	261	WP_072104698.1	YdaS family helix-turn-helix protein	-
JMJ86_RS09965	2086094..2086588	+	495	WP_219165085.1	hypothetical protein	-
JMJ86_RS09970	2086633..2087502	+	870	WP_058111754.1	hypothetical protein	-
JMJ86_RS09975	2087509..2088261	+	753	WP_219165083.1	ATP-binding protein	-
JMJ86_RS09980	2088279..2088674	+	396	WP_047588288.1	DUF977 family protein	-
JMJ86_RS09985	2088671..2088943	+	273	WP_000687976.1	hypothetical protein	-
-	2089076..2089134	-	59	-	-	Antitoxin
JMJ86_RS09990	2089146..2089301	+	156	WP_001597144.1	Hok/Gef family protein	Toxin
JMJ86_RS09995	2089540..2089707	+	168	WP_175441067.1	hypothetical protein	-
JMJ86_RS24575	2089768..2089848	+	81	Protein_1969	hypothetical protein	-
JMJ86_RS10000	2089878..2090315	+	438	WP_079809896.1	recombination protein NinB	-
JMJ86_RS24580	2090312..2090506	+	195	WP_072142230.1	hypothetical protein	-
JMJ86_RS10005	2090503..2090784	+	282	WP_057519936.1	DUF1364 family protein	-
JMJ86_RS10010	2090781..2091359	+	579	WP_079809895.1	DUF1133 family protein	-
JMJ86_RS10015	2091502..2092893	+	1392	WP_031571465.1	ATP-binding protein	-
JMJ86_RS10020	2092991..2093299	+	309	WP_000177624.1	HP1 family phage holin	-
JMJ86_RS10025	2093277..2093816	+	540	WP_079809894.1	lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2076398..2129744	53346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5742.91 Da
• Isoelectric Point: 6.1531

>T210174 WP_001597144.1 NZ_CP079836:2089146-2089301 [Salmonella enterica subsp. salamae]
MKQQKAMLIALIVICITVVMAVLVTRKDLCEVRIRTGQTEVAVFTAYESEE

Nucleotide

• Length: 156 bp

>T210174 NZ_CP104448:c3963053-3962871 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT210174 NZ_CP079836:c2089134-2089076 [Salmonella enterica subsp. salamae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A636EVM3

Antitoxin