Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1902428..1903128 Replicon chromosome
Accession NZ_CP079827
Organism Pseudomonas sp. HD6515

Toxin (Protein)


Gene name mqsR Uniprot ID A0A2I0CDW7
Locus tag KW568_RS08865 Protein ID WP_003254238.1
Coordinates 1902428..1902724 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID I7AUJ7
Locus tag KW568_RS08870 Protein ID WP_003254235.1
Coordinates 1902727..1903128 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW568_RS08845 (KW568_08790) 1898064..1899689 + 1626 WP_259538087.1 twin-arginine translocation signal domain-containing protein -
KW568_RS08850 (KW568_08795) 1899811..1900287 + 477 WP_003254241.1 sigma-70 family RNA polymerase sigma factor -
KW568_RS08855 (KW568_08800) 1900456..1900935 + 480 WP_003254240.1 hypothetical protein -
KW568_RS08860 (KW568_08805) 1901008..1902333 + 1326 WP_004573659.1 MFS transporter -
KW568_RS08865 (KW568_08810) 1902428..1902724 + 297 WP_003254238.1 type II toxin-antitoxin system MqsR family toxin Toxin
KW568_RS08870 (KW568_08815) 1902727..1903128 + 402 WP_003254235.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
KW568_RS08875 (KW568_08820) 1903200..1904882 - 1683 WP_010954959.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
KW568_RS08880 (KW568_08825) 1905418..1906167 + 750 WP_003254232.1 electron transfer flavoprotein subunit beta/FixA family protein -
KW568_RS08885 (KW568_08830) 1906169..1907110 + 942 WP_004573654.1 FAD-binding protein -
KW568_RS08890 (KW568_08835) 1907186..1908007 + 822 WP_004573652.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11110.18 Da        Isoelectric Point: 10.2270

>T210168 WP_003254238.1 NZ_CP079827:1902428-1902724 [Pseudomonas sp. HD6515]
MEKRMPNCPLERVKALAAARRIRPTGAALKGAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVWQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKEL

Download         Length: 297 bp

>T210168 NZ_CP104447:272385-272672 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14684.76 Da        Isoelectric Point: 4.9531

>AT210168 WP_003254235.1 NZ_CP079827:1902727-1903128 [Pseudomonas sp. HD6515]
MRCPICGGSELAPDIQGMPYSYKGEMTVIPEVSGDYCSACGECVLSHDEAMRVSHLMTAFERQVNANVVDPSFIASIRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp

>AT210168 NZ_CP104447:272659-272973 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I0CDW7

Antitoxin

Source ID Structure
AlphaFold DB I7AUJ7

References