Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 4628399..4629243 | Replicon | chromosome |
| Accession | NC_005126 | ||
| Organism | Photorhabdus luminescens subsp. laumondii TTO1 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | Q7N0E6 |
| Locus tag | PLU_RS19555 | Protein ID | WP_011148078.1 |
| Coordinates | 4628755..4629243 (+) | Length | 163 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | Q7N0E7 |
| Locus tag | PLU_RS19550 | Protein ID | WP_011148077.1 |
| Coordinates | 4628399..4628749 (+) | Length | 117 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PLU_RS19525 (plu3938) | 4623441..4624040 | + | 600 | WP_011148072.1 | hypothetical protein | - |
| PLU_RS19530 (plu3939) | 4624051..4625166 | + | 1116 | WP_011148073.1 | XRE family transcriptional regulator | - |
| PLU_RS19535 (plu3940) | 4625313..4625738 | - | 426 | WP_011148074.1 | TonB system transport protein ExbD | - |
| PLU_RS19540 (plu3941) | 4625742..4626713 | - | 972 | WP_041381122.1 | tonB-system energizer ExbB | - |
| PLU_RS19545 (plu3942) | 4627060..4628250 | + | 1191 | WP_011148076.1 | cystathionine beta-lyase | - |
| PLU_RS19550 (plu3943) | 4628399..4628749 | + | 351 | WP_011148077.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| PLU_RS19555 (plu3944) | 4628755..4629243 | + | 489 | WP_011148078.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| PLU_RS19560 (plu3945) | 4629388..4630059 | + | 672 | WP_011148079.1 | DedA family protein | - |
| PLU_RS19565 (plu3946) | 4630459..4631337 | + | 879 | WP_011148080.1 | 2,5-didehydrogluconate reductase DkgA | - |
| PLU_RS19570 (plu3947) | 4631472..4632893 | - | 1422 | WP_011148081.1 | cell division protein FtsP | - |
| PLU_RS19575 (plu3948) | 4633298..4634026 | - | 729 | WP_011148082.1 | 1-acylglycerol-3-phosphate O-acyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 163 a.a. Molecular weight: 19108.94 Da Isoelectric Point: 9.5494
>T21016 WP_011148078.1 NC_005126:4628755-4629243 [Photorhabdus laumondii subsp. laumondii TTO1]
MYDRVCVINGWALFAHPCFVEQLKQSIDKVEQLQQKYPNDYLKKNDTKRLAAIIKLVTEIIPNDPTNIAFRLGDTLGGKR
KHWFRAKFFQQYRLFFRFHAESKIIIFGWVNDERTKRAYGDKHDAYKVFGEMLNAGHPPDDWNSLLKESIDSPHLTKLIN
EH
MYDRVCVINGWALFAHPCFVEQLKQSIDKVEQLQQKYPNDYLKKNDTKRLAAIIKLVTEIIPNDPTNIAFRLGDTLGGKR
KHWFRAKFFQQYRLFFRFHAESKIIIFGWVNDERTKRAYGDKHDAYKVFGEMLNAGHPPDDWNSLLKESIDSPHLTKLIN
EH
Download Length: 489 bp
>T21016 NC_005126:4628755-4629243 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGTATGATCGAGTATGTGTAATAAACGGATGGGCTCTTTTTGCTCATCCGTGCTTTGTAGAACAATTAAAACAATCAAT
AGATAAGGTAGAACAACTTCAACAAAAATATCCAAATGACTACTTGAAAAAAAATGATACAAAACGCTTGGCTGCAATCA
TAAAACTCGTTACTGAAATTATTCCCAATGACCCAACTAATATAGCCTTTCGTTTAGGTGACACATTAGGTGGCAAAAGA
AAACACTGGTTCAGAGCAAAATTTTTCCAACAATATCGCCTTTTTTTCCGTTTTCACGCTGAAAGTAAAATTATTATCTT
TGGCTGGGTAAATGATGAGAGAACAAAAAGGGCATATGGTGATAAGCACGATGCTTACAAAGTATTTGGTGAAATGCTTA
ATGCAGGACACCCACCAGACGACTGGAACTCTCTTTTAAAAGAATCCATTGATTCACCACACTTAACTAAACTTATTAAT
GAACATTAG
ATGTATGATCGAGTATGTGTAATAAACGGATGGGCTCTTTTTGCTCATCCGTGCTTTGTAGAACAATTAAAACAATCAAT
AGATAAGGTAGAACAACTTCAACAAAAATATCCAAATGACTACTTGAAAAAAAATGATACAAAACGCTTGGCTGCAATCA
TAAAACTCGTTACTGAAATTATTCCCAATGACCCAACTAATATAGCCTTTCGTTTAGGTGACACATTAGGTGGCAAAAGA
AAACACTGGTTCAGAGCAAAATTTTTCCAACAATATCGCCTTTTTTTCCGTTTTCACGCTGAAAGTAAAATTATTATCTT
TGGCTGGGTAAATGATGAGAGAACAAAAAGGGCATATGGTGATAAGCACGATGCTTACAAAGTATTTGGTGAAATGCTTA
ATGCAGGACACCCACCAGACGACTGGAACTCTCTTTTAAAAGAATCCATTGATTCACCACACTTAACTAAACTTATTAAT
GAACATTAG
Antitoxin
Download Length: 117 a.a. Molecular weight: 12842.53 Da Isoelectric Point: 4.9246
>AT21016 WP_011148077.1 NC_005126:4628399-4628749 [Photorhabdus laumondii subsp. laumondii TTO1]
MHALPNVEFEVGAESKLTSRSQTTIPTSVRKALKLKPGHDSIAYKILSSGDVLISRKNSEEEKDLVMESFLDFLAKDIRR
HPGQVQQLDEQLINQAKSLIAGIDIDLSNPLSADDE
MHALPNVEFEVGAESKLTSRSQTTIPTSVRKALKLKPGHDSIAYKILSSGDVLISRKNSEEEKDLVMESFLDFLAKDIRR
HPGQVQQLDEQLINQAKSLIAGIDIDLSNPLSADDE
Download Length: 351 bp
>AT21016 NC_005126:4628399-4628749 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCACGCATTACCAAATGTTGAGTTCGAGGTTGGTGCAGAATCCAAGCTTACCAGTCGCAGCCAGACAACCATCCCAAC
ATCTGTCCGTAAAGCGCTTAAGTTAAAACCAGGTCATGACAGTATCGCATATAAGATTTTATCTTCTGGTGATGTACTTA
TCAGCCGTAAAAATAGTGAAGAAGAAAAAGATCTTGTCATGGAATCATTTCTGGACTTTCTGGCAAAAGACATTCGGAGA
CATCCGGGACAAGTACAACAATTAGATGAACAACTCATTAACCAGGCGAAGTCACTTATCGCTGGAATAGACATAGATCT
GAGCAACCCATTATCTGCTGACGATGAGTAA
ATGCACGCATTACCAAATGTTGAGTTCGAGGTTGGTGCAGAATCCAAGCTTACCAGTCGCAGCCAGACAACCATCCCAAC
ATCTGTCCGTAAAGCGCTTAAGTTAAAACCAGGTCATGACAGTATCGCATATAAGATTTTATCTTCTGGTGATGTACTTA
TCAGCCGTAAAAATAGTGAAGAAGAAAAAGATCTTGTCATGGAATCATTTCTGGACTTTCTGGCAAAAGACATTCGGAGA
CATCCGGGACAAGTACAACAATTAGATGAACAACTCATTAACCAGGCGAAGTCACTTATCGCTGGAATAGACATAGATCT
GAGCAACCCATTATCTGCTGACGATGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JMX9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JML2 |