Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
Location | 4022246..4022843 | Replicon | chromosome |
Accession | NZ_CP079807 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC02_S465MC |
Toxin (Protein)
Gene name | higB | Uniprot ID | R4YIC5 |
Locus tag | KWL80_RS19845 | Protein ID | WP_004142563.1 |
Coordinates | 4022526..4022843 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | R4YH91 |
Locus tag | KWL80_RS19840 | Protein ID | WP_004142561.1 |
Coordinates | 4022246..4022533 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KWL80_RS19810 (4018341) | 4018341..4018589 | + | 249 | WP_002893037.1 | DUF1158 domain-containing protein | - |
KWL80_RS19815 (4018607) | 4018607..4018948 | - | 342 | WP_002893035.1 | RamA family antibiotic efflux transcriptional regulator | - |
KWL80_RS19820 (4018979) | 4018979..4020094 | - | 1116 | WP_012737592.1 | MBL fold metallo-hydrolase | - |
KWL80_RS19825 (4020274) | 4020274..4020858 | + | 585 | WP_071579668.1 | TetR/AcrR family transcriptional regulator | - |
KWL80_RS19830 (4020855) | 4020855..4021223 | + | 369 | WP_040171587.1 | MmcQ/YjbR family DNA-binding protein | - |
KWL80_RS19835 (4021343) | 4021343..4021981 | + | 639 | WP_064277739.1 | oxygen-insensitive NAD(P)H nitroreductase | - |
KWL80_RS19840 (4022246) | 4022246..4022533 | - | 288 | WP_004142561.1 | helix-turn-helix transcriptional regulator | Antitoxin |
KWL80_RS19845 (4022526) | 4022526..4022843 | - | 318 | WP_004142563.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KWL80_RS19850 (4023028) | 4023028..4024071 | - | 1044 | WP_040153598.1 | DUF2157 domain-containing protein | - |
KWL80_RS19855 (4024741) | 4024741..4025607 | - | 867 | WP_004151823.1 | helix-turn-helix transcriptional regulator | - |
KWL80_RS19860 (4025716) | 4025716..4027143 | + | 1428 | WP_009308097.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12110.39 Da Isoelectric Point: 11.2767
>T210147 WP_004142563.1 NZ_CP079807:c4022843-4022526 [Klebsiella pneumoniae subsp. pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE
Download Length: 318 bp
>T210147 NZ_CP104442:c1016907-1016734 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10771.46 Da Isoelectric Point: 10.2212
>AT210147 WP_004142561.1 NZ_CP079807:c4022533-4022246 [Klebsiella pneumoniae subsp. pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY
Download Length: 288 bp
>AT210147 NZ_CP104442:c1017231-1016935 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M5MXH8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0S3DIQ1 |