Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 349269..349915 Replicon chromosome
Accession NZ_CP079781
Organism Klebsiella pneumoniae subsp. pneumoniae strain T698-1

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag KYY07_RS01610 Protein ID WP_002920560.1
Coordinates 349269..349616 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag KYY07_RS01615 Protein ID WP_002920557.1
Coordinates 349616..349915 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYY07_RS01600 (KYY07_01600) 345195..346628 + 1434 WP_002920564.1 glycogen synthase GlgA -
KYY07_RS01605 (KYY07_01605) 346646..349093 + 2448 WP_002920561.1 glycogen phosphorylase -
KYY07_RS01610 (KYY07_01610) 349269..349616 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYY07_RS01615 (KYY07_01615) 349616..349915 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
KYY07_RS01620 (KYY07_01620) 349978..351486 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
KYY07_RS01625 (KYY07_01625) 351691..352020 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KYY07_RS01630 (KYY07_01630) 352071..352901 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KYY07_RS01635 (KYY07_01635) 352951..353709 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T210083 WP_002920560.1 NZ_CP079781:349269-349616 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T210083 NZ_CP104386:2342902-2343078 [Cupriavidus gilardii]
GTGAAGCAGAGCGAGTTCAGACGCTGGCTAGGCCGGCAAGGCGCGACCTTCGCCGACGGCGGAAAGCACCTGAAGGTCTA
TCTCAACGGCCGACAGAGCACGATGCCGCGGCATCCCGGAAAGGAAATCGCCGAACGCACGCGCAAGGCCATCCTGAAGC
AACTTGGATTGGCGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT210083 WP_002920557.1 NZ_CP079781:349616-349915 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT210083 NZ_CP104386:2343118-2343534 [Cupriavidus gilardii]
ATGCTGCGCTACCCCGTCATCCTCACCGCCGACGACGATGGTGTGGCGGTCTCCTTCCCGGACATCCCCGAGGCATTGAC
CTGCGGTGACTCGCACGAAGAGGCCTTGCAGATGGCCGCCGATGCCCTTGTGACGGCGATGGAGTTCTATTTCGAGGATC
GGCGGCCGGTGCCGATGCCCTCGGCTCCCGAGGTAGGGCAGGAACTGGTCGACCTGCCCGCGAGCCTGTCCGCAAAGGTC
TTGCTGCTGAACGAAATGCTTTCGCAGAAGGTCAGCCAGTCGGAACTGGCACGGCGCTTGGATACCCGACCGCAGGAAGT
CCAGCGCATCGTCAATCTCGATCACACGACCAAGATCGACACGATCGAGGCTGCCTTTCGGGCGCTCGGCAGGCGGATAG
AACTGCGAATTACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References