Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 323079..323665 Replicon chromosome
Accession NZ_CP079781
Organism Klebsiella pneumoniae subsp. pneumoniae strain T698-1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KYY07_RS01500 Protein ID WP_002920800.1
Coordinates 323297..323665 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag KYY07_RS01495 Protein ID WP_002920802.1
Coordinates 323079..323300 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYY07_RS01475 (KYY07_01475) 319236..320162 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KYY07_RS01480 (KYY07_01480) 320159..321436 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
KYY07_RS01485 (KYY07_01485) 321433..322200 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KYY07_RS01490 (KYY07_01490) 322202..322915 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KYY07_RS01495 (KYY07_01495) 323079..323300 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYY07_RS01500 (KYY07_01500) 323297..323665 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KYY07_RS01505 (KYY07_01505) 323938..325254 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KYY07_RS01510 (KYY07_01510) 325361..326248 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KYY07_RS01515 (KYY07_01515) 326245..327090 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KYY07_RS01520 (KYY07_01520) 327092..328162 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 320159..328899 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T210082 WP_002920800.1 NZ_CP079781:323297-323665 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T210082 NZ_CP104386:c1027654-1027373 [Cupriavidus gilardii]
ATGATCCAATCATTCCGATGCATGGACACGCGAGCCCTCTTTGAAGGCAAGCGCGTTGCACGTTTTACCAACATCCACGC
AGTTGCGGAACGCAAACTGCAGATGTTGGAGTCCGCCACCACACTGGCCTCGTTAATGGCTCCGCCAGGCAATCGGCTGG
AAATCCTCTCGGGCAATCGACGGGGCCAGTACAGCATCAGGGTGAACGCCCAATGGCGGATTTGTTTCCTCTGGACCTCC
GAAGGTCCACAGTGCGTAGAAATTGTGGACTACCATGATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT210082 WP_002920802.1 NZ_CP079781:323079-323300 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT210082 NZ_CP104386:c1027380-1027027 [Cupriavidus gilardii]
ATGATTGAGTTCAACAACAACGTTGGCGAGGAGTTCGCTATGGCGCGTTTTCACAACGGCATGCGCCCGGTTCATCCGGG
CGAGATCCTGCGCGAGGAGTATCTGGTGCCGCTCGATCTATCGATCGCGGAACTGGCGAAGGAATTGCATATCGACACCG
CGCAGATCGACGCGATCGTCCGGGGCGATGCCGGCGTGGCCAGCGAGATCGCTCTGCGTTTGGCGCGCTATTTTGGTGGT
GACGCCGAAACCTGGTTGAACCTTCAGCAGGCCTACGATCTCAAGACCGCCGAACAGCAGGTCGGCGACGCCATTCGTTC
CGAAGTCGCGCCGCGCAAGGCCAAGGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References