Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2190443..2191136 Replicon chromosome
Accession NZ_CP079780
Organism Escherichia coli strain BL12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KYX59_RS12880 Protein ID WP_000415584.1
Coordinates 2190840..2191136 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KYX59_RS12875 Protein ID WP_000650107.1
Coordinates 2190443..2190838 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX59_RS12865 (2186307) 2186307..2188565 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
KYX59_RS12870 (2188703) 2188703..2190310 - 1608 WP_148116248.1 ABC transporter substrate-binding protein -
KYX59_RS12875 (2190443) 2190443..2190838 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KYX59_RS12880 (2190840) 2190840..2191136 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KYX59_RS12885 (2191341) 2191341..2191823 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KYX59_RS12890 (2191876) 2191876..2192268 - 393 WP_148116247.1 OB fold stress tolerance protein YgiW -
KYX59_RS12895 (2192420) 2192420..2193079 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KYX59_RS12900 (2193076) 2193076..2194425 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KYX59_RS12905 (2194471) 2194471..2194803 - 333 WP_000917684.1 DUF2645 family protein -
KYX59_RS12910 (2195122) 2195122..2195703 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KYX59_RS12915 (2195734) 2195734..2196048 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T210073 WP_000415584.1 NZ_CP079780:c2191136-2190840 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T210073 NZ_CP104384:2674077-2674184 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTTGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT210073 WP_000650107.1 NZ_CP079780:c2190838-2190443 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT210073 NZ_CP104384:c2674030-2673964 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References