Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 447959..448330 | Replicon | chromosome |
| Accession | NZ_CP079780 | ||
| Organism | Escherichia coli strain BL12 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | F4VC37 |
| Locus tag | KYX59_RS04195 | Protein ID | WP_001317028.1 |
| Coordinates | 448136..448330 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 447959..448137 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX59_RS04170 (443914) | 443914..445287 | + | 1374 | WP_259482750.1 | ATP-dependent RNA helicase DbpA | - |
| KYX59_RS04175 (445416) | 445416..446351 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| KYX59_RS04180 (446403) | 446403..447638 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
| KYX59_RS04185 (447640) | 447640..447855 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (447959) | 447959..448137 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (447959) | 447959..448137 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (447959) | 447959..448137 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (447959) | 447959..448137 | + | 179 | NuclAT_0 | - | Antitoxin |
| KYX59_RS04190 (447934) | 447934..448143 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
| KYX59_RS04195 (448136) | 448136..448330 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| KYX59_RS04200 (448387) | 448387..449196 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
| KYX59_RS04205 (449189) | 449189..451789 | - | 2601 | WP_024232464.1 | exodeoxyribonuclease VIII | - |
| KYX59_RS04210 (451891) | 451891..452166 | - | 276 | WP_000632297.1 | protein RacC | - |
| KYX59_RS04215 (452241) | 452241..452411 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| KYX59_RS04220 (452411) | 452411..452632 | - | 222 | WP_000560223.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 443914..473467 | 29553 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T210055 WP_001317028.1 NZ_CP079780:c448330-448136 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T210055 NZ_CP079780:c448330-448136 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT210055 NZ_CP079780:447959-448137 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
