Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4191265..4191958 Replicon chromosome
Accession NZ_CP079767
Organism Escherichia coli strain SF10

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KX927_RS22860 Protein ID WP_000415584.1
Coordinates 4191265..4191561 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KX927_RS22865 Protein ID WP_000650107.1
Coordinates 4191563..4191958 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX927_RS22825 (4186353) 4186353..4186667 - 315 WP_000958598.1 putative quinol monooxygenase -
KX927_RS22830 (4186698) 4186698..4187279 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KX927_RS22835 (4187598) 4187598..4187930 + 333 WP_000917684.1 DUF2645 family protein -
KX927_RS22840 (4187976) 4187976..4189325 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KX927_RS22845 (4189322) 4189322..4189981 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
KX927_RS22850 (4190133) 4190133..4190525 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KX927_RS22855 (4190578) 4190578..4191060 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KX927_RS22860 (4191265) 4191265..4191561 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KX927_RS22865 (4191563) 4191563..4191958 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KX927_RS22870 (4192091) 4192091..4193698 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KX927_RS22875 (4193836) 4193836..4196094 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 4131712..4196094 64382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T209986 WP_000415584.1 NZ_CP079767:4191265-4191561 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T209986 NZ_CP104358:c4078882-4078598 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT209986 WP_000650107.1 NZ_CP079767:4191563-4191958 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT209986 NZ_CP104358:c4079114-4078872 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References