Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1444292..1444900 Replicon chromosome
Accession NZ_CP079758
Organism Pseudomonas aeruginosa strain PA0386

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag KYE95_RS06785 Protein ID WP_003114156.1
Coordinates 1444553..1444900 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KYE95_RS06780 Protein ID WP_003114155.1
Coordinates 1444292..1444543 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYE95_RS06760 (KYE95_06755) 1439939..1440295 + 357 WP_003114150.1 DUF2523 family protein -
KYE95_RS06765 (KYE95_06760) 1440299..1441573 + 1275 WP_010895520.1 zonular occludens toxin family protein -
KYE95_RS06770 (KYE95_06765) 1441803..1443095 + 1293 WP_003115206.1 hypothetical protein -
KYE95_RS06775 (KYE95_06770) 1443095..1444078 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
KYE95_RS06780 (KYE95_06775) 1444292..1444543 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYE95_RS06785 (KYE95_06780) 1444553..1444900 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYE95_RS06795 (KYE95_06790) 1445227..1446129 - 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
KYE95_RS06800 (KYE95_06795) 1446581..1447318 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
KYE95_RS06805 (KYE95_06800) 1447398..1448441 - 1044 WP_003098363.1 L,D-transpeptidase -
KYE95_RS06810 (KYE95_06805) 1448577..1449269 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
KYE95_RS06815 (KYE95_06810) 1449269..1449541 - 273 WP_010895521.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage catB7 - 1425611..1444900 19289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T209927 WP_003114156.1 NZ_CP079758:1444553-1444900 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T209927 NZ_CP104342:1255126-1255308 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT209927 WP_003114155.1 NZ_CP079758:1444292-1444543 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT209927 NZ_CP104342:1255401-1255805 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References