Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1663033..1663617 Replicon chromosome
Accession NZ_CP079748
Organism Acinetobacter johnsonii strain MR1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KXJ74_RS08110 Protein ID WP_219191538.1
Coordinates 1663033..1663314 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KXJ74_RS08115 Protein ID WP_219191539.1
Coordinates 1663333..1663617 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ74_RS08060 (KXJ74_08060) 1658086..1658358 + 273 WP_219191532.1 hypothetical protein -
KXJ74_RS08065 (KXJ74_08065) 1658476..1658733 + 258 Protein_1572 DUF2280 domain-containing protein -
KXJ74_RS08070 (KXJ74_08070) 1658711..1659265 + 555 WP_219191534.1 hypothetical protein -
KXJ74_RS08075 (KXJ74_08075) 1659546..1659842 + 297 WP_219191535.1 hypothetical protein -
KXJ74_RS08080 (KXJ74_08080) 1660121..1660624 + 504 WP_228738003.1 leucine-rich repeat protein -
KXJ74_RS08085 (KXJ74_08085) 1660726..1660923 + 198 WP_219191536.1 hypothetical protein -
KXJ74_RS08090 (KXJ74_08090) 1660989..1661249 + 261 WP_228737965.1 hypothetical protein -
KXJ74_RS08095 (KXJ74_08095) 1661230..1661817 + 588 WP_219191693.1 N-acetylmuramidase family protein -
KXJ74_RS08100 (KXJ74_08100) 1662102..1662380 + 279 WP_219191537.1 DUF2164 domain-containing protein -
KXJ74_RS08105 (KXJ74_08105) 1662515..1662823 - 309 WP_130146814.1 hypothetical protein -
KXJ74_RS08110 (KXJ74_08110) 1663033..1663314 + 282 WP_219191538.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXJ74_RS08115 (KXJ74_08115) 1663333..1663617 + 285 WP_219191539.1 HigA family addiction module antitoxin Antitoxin
KXJ74_RS08120 (KXJ74_08120) 1663642..1664394 - 753 WP_228737967.1 hypothetical protein -
KXJ74_RS08125 (KXJ74_08125) 1664546..1664767 - 222 WP_130146820.1 excalibur calcium-binding domain-containing protein -
KXJ74_RS08130 (KXJ74_08130) 1664955..1665614 + 660 WP_219191541.1 hypothetical protein -
KXJ74_RS08135 (KXJ74_08135) 1665838..1666698 + 861 WP_219191542.1 hypothetical protein -
KXJ74_RS08140 (KXJ74_08140) 1666781..1667143 - 363 WP_219191543.1 Arc family DNA-binding protein -
KXJ74_RS08145 (KXJ74_08145) 1667311..1668111 + 801 WP_219191544.1 BRO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1637923..1668111 30188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10653.17 Da        Isoelectric Point: 9.9524

>T209892 WP_219191538.1 NZ_CP079748:1663033-1663314 [Acinetobacter johnsonii]
MIKSFKHKGLQAFFQTGTTAGIQATHSSKLRLILAALHAASTVNDLRIPPNWRLHKLNGNLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYH

Download         Length: 282 bp

>T209892 NZ_CP104330:c1802667-1802293 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10624.18 Da        Isoelectric Point: 6.2127

>AT209892 WP_219191539.1 NZ_CP079748:1663333-1663617 [Acinetobacter johnsonii]
MNMMFNAPHPGEMLREYMGETPVTEAAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWNASQ
RQRPVIKKLVQDFA

Download         Length: 285 bp

>AT209892 NZ_CP104330:c1803124-1802756 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References