209873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 736545..737238 Replicon chromosome
Accession NZ_CP079747
Organism Escherichia coli strain DL21

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KXJ73_RS03590 Protein ID WP_000415584.1
Coordinates 736545..736841 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KXJ73_RS03595 Protein ID WP_000650107.1
Coordinates 736843..737238 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ73_RS03555 (731633) 731633..731947 - 315 WP_000958598.1 putative quinol monooxygenase -
KXJ73_RS03560 (731978) 731978..732559 - 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
KXJ73_RS03565 (732878) 732878..733210 + 333 WP_000917684.1 DUF2645 family protein -
KXJ73_RS03570 (733256) 733256..734605 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KXJ73_RS03575 (734602) 734602..735261 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KXJ73_RS03580 (735413) 735413..735805 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KXJ73_RS03585 (735858) 735858..736340 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KXJ73_RS03590 (736545) 736545..736841 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KXJ73_RS03595 (736843) 736843..737238 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KXJ73_RS03600 (737371) 737371..738978 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KXJ73_RS03605 (739116) 739116..741374 + 2259 WP_001281877.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T209873 WP_000415584.1 NZ_CP079747:736545-736841 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T209873 NZ_CP104328:3595299-3595577 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT209873 WP_000650107.1 NZ_CP079747:736843-737238 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT209873 NZ_CP104328:3595036-3595296 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References