209844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1791143..1791645 Replicon chromosome
Accession NZ_CP079736
Organism Escherichia coli strain GB2005-delet-a-f

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag KYX13_RS08525 Protein ID WP_000767829.1
Coordinates 1791391..1791645 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KYX13_RS08520 Protein ID WP_001259255.1
Coordinates 1791143..1791394 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX13_RS08495 (1786321) 1786321..1787388 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KYX13_RS08500 (1787388) 1787388..1788458 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
KYX13_RS08505 (1788455) 1788455..1789759 - 1305 WP_000009594.1 histidinol dehydrogenase -
KYX13_RS08510 (1789765) 1789765..1790664 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
KYX13_RS08515 (1790810) 1790810..1790860 - 51 WP_001364200.1 his operon leader peptide -
KYX13_RS08520 (1791143) 1791143..1791394 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KYX13_RS08525 (1791391) 1791391..1791645 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KYX13_RS08530 (1791728) 1791728..1792552 + 825 WP_000754737.1 SDR family oxidoreductase -
KYX13_RS08535 (1792598) 1792598..1793527 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
KYX13_RS08540 (1793742) 1793742..1793804 + 63 WP_010723108.1 membrane protein YoeI -
KYX13_RS08545 (1793794) 1793794..1795152 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
KYX13_RS08550 (1795331) 1795331..1796389 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
KYX13_RS08555 (1796403) 1796403..1796630 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T209844 WP_000767829.1 NZ_CP079736:1791391-1791645 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T209844 NZ_CP104326:3946472-3946813 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT209844 WP_001259255.1 NZ_CP079736:1791143-1791394 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT209844 NZ_CP104326:c3946477-3946401 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References