209839

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 719143..719836 Replicon chromosome
Accession NZ_CP079736
Organism Escherichia coli strain GB2005-delet-a-f

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KYX13_RS03495 Protein ID WP_000415584.1
Coordinates 719143..719439 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KYX13_RS03500 Protein ID WP_000650107.1
Coordinates 719441..719836 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX13_RS03460 (714231) 714231..714545 - 315 WP_000958598.1 putative quinol monooxygenase -
KYX13_RS03465 (714576) 714576..715157 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KYX13_RS03470 (715476) 715476..715808 + 333 WP_000917684.1 DUF2645 family protein -
KYX13_RS03475 (715854) 715854..717203 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KYX13_RS03480 (717200) 717200..717859 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
KYX13_RS03485 (718011) 718011..718403 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KYX13_RS03490 (718456) 718456..718938 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KYX13_RS03495 (719143) 719143..719439 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KYX13_RS03500 (719441) 719441..719836 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KYX13_RS03505 (719969) 719969..721576 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KYX13_RS03510 (721714) 721714..723972 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T209839 WP_000415584.1 NZ_CP079736:719143-719439 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T209839 NZ_CP104326:2615870-2615977 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT209839 WP_000650107.1 NZ_CP079736:719441-719836 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT209839 NZ_CP104326:c2615820-2615757 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References