209837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 609886..610685 Replicon chromosome
Accession NZ_CP079736
Organism Escherichia coli strain GB2005-delet-a-f

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag KYX13_RS02960 Protein ID WP_000347273.1
Coordinates 609886..610350 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KYX13_RS02965 Protein ID WP_001307405.1
Coordinates 610350..610685 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX13_RS02935 (606062) 606062..606619 - 558 Protein_577 amidohydrolase family protein -
KYX13_RS02940 (606615) 606615..606986 - 372 Protein_578 PTS sugar transporter subunit IIC -
KYX13_RS02945 (606997) 606997..607470 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
KYX13_RS02950 (607493) 607493..608773 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
KYX13_RS02955 (609022) 609022..609831 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KYX13_RS02960 (609886) 609886..610350 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KYX13_RS02965 (610350) 610350..610685 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KYX13_RS02970 (610834) 610834..612405 - 1572 WP_001273753.1 galactarate dehydratase -
KYX13_RS02975 (612780) 612780..614114 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
KYX13_RS02980 (614130) 614130..614900 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 598902..621560 22658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T209837 WP_000347273.1 NZ_CP079736:c610350-609886 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T209837 NZ_CP104326:2614800-2614907 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT209837 WP_001307405.1 NZ_CP079736:c610685-610350 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT209837 NZ_CP104326:c2614753-2614687 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References