Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 29222..29953 Replicon plasmid pHD6416-NDM
Accession NZ_CP079717
Organism Shewanella xiamenensis strain HD6416

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KXJ80_RS00200 Protein ID WP_259474369.1
Coordinates 29651..29953 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KXJ80_RS00195 Protein ID WP_259474368.1
Coordinates 29222..29641 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ80_RS00140 (KXJ80_00135) 24450..24704 - 255 WP_069455593.1 hypothetical protein -
KXJ80_RS00145 (KXJ80_00140) 24697..25077 - 381 WP_069455594.1 hypothetical protein -
KXJ80_RS00150 (KXJ80_00145) 25148..25486 - 339 WP_259474363.1 hypothetical protein -
KXJ80_RS00155 (KXJ80_00150) 26368..26622 - 255 WP_069455598.1 hypothetical protein -
KXJ80_RS00160 (KXJ80_00155) 26652..27008 - 357 WP_259474364.1 hypothetical protein -
KXJ80_RS00165 (KXJ80_00160) 27021..27314 - 294 WP_219640048.1 hypothetical protein -
KXJ80_RS00170 (KXJ80_00165) 27328..27576 - 249 WP_139122718.1 hypothetical protein -
KXJ80_RS00175 (KXJ80_00170) 27654..27914 - 261 WP_259474365.1 hypothetical protein -
KXJ80_RS00180 (KXJ80_00175) 28161..28640 - 480 WP_259474366.1 transposase -
KXJ80_RS00185 (KXJ80_00180) 28668..28901 - 234 WP_259474367.1 hypothetical protein -
KXJ80_RS00190 (KXJ80_00185) 28894..29142 - 249 WP_139122718.1 hypothetical protein -
KXJ80_RS00195 (KXJ80_00190) 29222..29641 - 420 WP_259474368.1 helix-turn-helix domain-containing protein Antitoxin
KXJ80_RS00200 (KXJ80_00195) 29651..29953 - 303 WP_259474369.1 type II toxin-antitoxin system HigB family toxin Toxin
KXJ80_RS00205 (KXJ80_00200) 30106..30771 - 666 WP_259474370.1 site-specific integrase -
KXJ80_RS00210 (KXJ80_00205) 31653..31895 + 243 WP_259474371.1 hypothetical protein -
KXJ80_RS00215 (KXJ80_00210) 31899..32078 + 180 WP_259474372.1 hypothetical protein -
KXJ80_RS00220 (KXJ80_00215) 32256..32582 + 327 WP_259474373.1 hypothetical protein -
KXJ80_RS00225 (KXJ80_00220) 32686..32838 - 153 WP_259474374.1 DUF4113 domain-containing protein -
KXJ80_RS00230 (KXJ80_00225) 33254..34123 + 870 WP_259474375.1 hypothetical protein -
KXJ80_RS00235 (KXJ80_00230) 34138..34404 - 267 WP_259474376.1 hypothetical protein -
KXJ80_RS00240 (KXJ80_00235) 34496..34951 - 456 WP_259474377.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA27 / aadA16 / qacE / sul1 / mph(A) / blaTEM-1B / aac(3)-IId / msr(E) / mph(E) / qnrVC6 / blaNDM-1 / catA2 - 1..206938 206938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11794.67 Da        Isoelectric Point: 10.1722

>T209780 WP_259474369.1 NZ_CP079717:c29953-29651 [Shewanella xiamenensis]
MHVISRKPFADAIKKFPNDASAIESTYNVLKRGDFKTPQELRAVFGSLDNFKYKDKWWIIDIGGNNLRMLAFIEFVHNRI
YVKHIVSHSEYDALCKKYRK

Download         Length: 303 bp

>T209780 NZ_CP079717:c29953-29651 [Shewanella xiamenensis]
ATGCACGTAATATCAAGAAAGCCTTTTGCTGATGCAATTAAGAAGTTTCCAAACGATGCCTCAGCGATTGAAAGCACATA
CAACGTGCTAAAACGTGGTGACTTTAAAACCCCACAAGAGCTTAGGGCGGTTTTTGGTTCATTGGACAATTTTAAGTACA
AGGATAAGTGGTGGATTATCGACATCGGCGGCAATAACTTAAGAATGCTGGCGTTTATCGAGTTCGTACACAATCGGATT
TATGTAAAGCATATCGTTTCCCACAGTGAGTACGATGCGCTTTGTAAGAAGTATAGAAAATAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15282.52 Da        Isoelectric Point: 4.4049

>AT209780 WP_259474368.1 NZ_CP079717:c29641-29222 [Shewanella xiamenensis]
MLAVAELTKLAGNIMSNVPLLAGISNAAEHQQALELMEELLDDYDANLVVIEALSNVIARYEDESLRFDMFNSRQAELDP
AVATLKVLMDQNGLNTTDFEAEIGKKSMVSQVLAGKKNLTKEHISKLAQRFGVNPAVFF

Download         Length: 420 bp

>AT209780 NZ_CP079717:c29641-29222 [Shewanella xiamenensis]
ATGTTAGCTGTAGCCGAATTAACAAAACTGGCGGGTAACATTATGTCGAATGTGCCTTTGCTGGCTGGCATTAGCAACGC
AGCAGAACATCAGCAAGCACTTGAACTGATGGAAGAACTGTTAGATGACTATGACGCGAATCTCGTGGTTATTGAAGCCC
TGAGCAACGTTATAGCGCGTTATGAGGATGAATCACTTCGGTTCGATATGTTCAACAGTAGACAGGCTGAACTTGATCCA
GCAGTTGCCACGTTAAAAGTGCTGATGGATCAGAACGGACTGAATACCACAGACTTTGAAGCTGAAATCGGCAAAAAAAG
TATGGTGTCGCAGGTATTGGCTGGAAAAAAGAACCTGACCAAAGAACACATTTCTAAGCTGGCTCAGCGCTTCGGCGTAA
ATCCAGCGGTATTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References