209760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 256823..257346 Replicon chromosome
Accession NZ_CP079715
Organism Staphylococcus aureus strain V8

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag KX797_RS01390 Protein ID WP_000074048.1
Coordinates 256823..257089 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KX797_RS01395 Protein ID WP_000587616.1
Coordinates 257089..257346 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX797_RS01370 (252130) 252130..253317 - 1188 WP_000026194.1 MFS transporter -
KX797_RS01375 (253713) 253713..254489 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KX797_RS01380 (254482) 254482..255144 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
KX797_RS01385 (255392) 255392..256468 - 1077 WP_001076671.1 M42 family metallopeptidase -
KX797_RS01390 (256823) 256823..257089 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
KX797_RS01395 (257089) 257089..257346 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KX797_RS01400 (257705) 257705..258160 + 456 WP_000732082.1 DUF1307 domain-containing protein -
KX797_RS01405 (258328) 258328..259905 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KX797_RS01410 (260100) 260100..260849 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
KX797_RS01415 (261073) 261073..262266 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T209760 WP_000074048.1 NZ_CP079715:c257089-256823 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T209760 NZ_CP104302:798332-798595 [Mycolicibacterium brumae]
ATGACCTACCGGGTCGAACTGACTCGACGCGCTCGGCGAAGTCTGTCCGAGGAGCTTCCCGAGGTTGTCGCCGCGGCTTG
CTGGGAGTTCATTCGTGGCCCGCTCGCCGAGAACCCGCATCGGGTCGGCAAGTGCCTGCGCGACGAGTTGGCCGGCCGCT
GGTCAGCGCGGCGTGGGGATTTCCGGGTCGTCTACGAGATTCATGAGAACGTCGTCGTCGTCCGGGTCATTGACGTTCGA
CATCGTCGTGACGCTTATCGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT209760 WP_000587616.1 NZ_CP079715:c257346-257089 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT209760 NZ_CP104302:798051-798335 [Mycolicibacterium brumae]
ATGACCACGTTGCCGATTGCCGAGGTGCGAGCCAACCTGTCCAAATTGGTGGACGAAGCCGTGCGCACGCATCAGCGGGT
CGAGGTCACCAAGAATGGGCGCCGCGCCGCCGTGCTGATCAGCGCCGACGACTACGACTCCCTCATGGAGACCCTCGAAA
TTCTCGGTGATCGAGAAGCGATGGACGCCCTCCGCGAGGCGGACGCCGATATCGCGGCCGGCCGGGTCTACCCGCTTGAC
GAGGTGGAAGCCGAACTCCGCGCGAAGGGCATCATCGGTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References