Detailed information of TA system TA209758

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 225323..225507
• Replicon: chromosome
• Accession: NZ_CP079715
• Organism: Staphylococcus aureus strain V8

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KX797_RS01250
• Protein ID: WP_000482650.1
• Coordinates: 225400..225507 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	225323..225383 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX797_RS01235	220853..221020	-	168	WP_001790576.1	hypothetical protein	-
KX797_RS01240	221251..222984	-	1734	WP_219098878.1	ABC transporter ATP-binding protein	-
KX797_RS01245	223009..224772	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	225323..225383	+	61	-	-	Antitoxin
KX797_RS01250	225400..225507	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
KX797_RS01255	225641..226027	-	387	WP_000779358.1	flippase GtxA	-
KX797_RS01260	226295..227437	+	1143	WP_219098879.1	glycerate kinase	-
KX797_RS01265	227497..228156	+	660	WP_000831298.1	membrane protein	-
KX797_RS01270	228338..229549	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KX797_RS01275	229672..230145	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T209758 WP_000482650.1 NZ_CP079715:c225507-225400 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T209758 NZ_CP104302:207524-207919 [Mycolicibacterium brumae]
GTGGCCTACTACGTCGACATTTCGGCGCTGGTGAAGTTGGTCGTCGCCGAGCCGGAAACACCCGCGTTGAGGGACTGGAT
TGCAGGCGAAAGCGCGGCATTGGTGTCGTCGGACGTGACTCGCACGGAATTGCTGCGCGCGGTCCGGCGAGTGGCCCCAG
AGCGTCTGGTTGAGGCGCGGGCGGTCCTCGACTCGATCATCCTCAGCACTGTCAGCACTGCGACCTTCGAAGCGGCCGCT
CTTCTGGACCCGACGGTCCTGCGCAGCCTTGACGCCGTGCACATTGCGGCCGCGCTCGAACTGGGAGACGACCTCGCCGG
CATGGTCACCTACGACGACCGGATGGCGGCTGCCGCACGGGCCCACGGGATCGCGGTTCTTGCGCCTTCCCAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT209758 NZ_CP079715:225323-225383 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin