Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 199971..200488 | Replicon | chromosome |
| Accession | NZ_CP079715 | ||
| Organism | Staphylococcus aureus strain V8 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KX797_RS01115 | Protein ID | WP_000113262.1 |
| Coordinates | 199971..200237 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KX797_RS01120 | Protein ID | WP_000584499.1 |
| Coordinates | 200237..200488 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KX797_RS01085 (195397) | 195397..195933 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KX797_RS01090 (196166) | 196166..196990 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| KX797_RS01095 (197207) | 197207..197389 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| KX797_RS01100 (197473) | 197473..197940 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| KX797_RS01105 (198126) | 198126..199676 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KX797_RS01110 (199865) | 199865..199936 | - | 72 | Protein_220 | hypothetical protein | - |
| KX797_RS01115 (199971) | 199971..200237 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KX797_RS01120 (200237) | 200237..200488 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KX797_RS01125 (200653) | 200653..200754 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| KX797_RS01130 (200761) | 200761..201360 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| KX797_RS01135 (201379) | 201379..201741 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KX797_RS01140 (201996) | 201996..203246 | + | 1251 | WP_219098876.1 | FemA/FemB family glycyltransferase FmhA | - |
| KX797_RS01145 (203343) | 203343..204074 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KX797_RS01150 (204071) | 204071..204790 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T209757 WP_000113262.1 NZ_CP079715:c200237-199971 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T209757 NZ_CP104302:c113344-112919 [Mycolicibacterium brumae]
ATGAACATCGTCGACGTCAACGTGCTGCTCTACGCCGTAAACCGCCAATCCGCCCAGCACAGCGCCGCGCACAGCTGGCT
GAGCGGCCAGTTGCGCGGGCCCGGGACCGTCGGGCTGTCGTGGACGGCGCTGCTCGGCTTCGTCAGAATCGCCACCAACC
CGTCGATCCTGCCCCGCCCGCTCCGTCCGGCCGAGGCCTTCGACATCATCGACGCGTGGCTGGCGTCCCCCGCCGCCGTC
GTCGTCGAACCGACCTCCCGGCATCTGGCGATCCTCCGCGGACTGCTCACCGAATTCGGAACGGCCGGAAATCTGACCAG
CGACGCGCACCTGGCCGCACTGGCCGTCGAGTACGGCGGCGTCGTGGTGACCTTCGACCGCGACTTCGCCCGGTTCGGCG
TCGACACCGTCACGCCGGCCGGATAG
ATGAACATCGTCGACGTCAACGTGCTGCTCTACGCCGTAAACCGCCAATCCGCCCAGCACAGCGCCGCGCACAGCTGGCT
GAGCGGCCAGTTGCGCGGGCCCGGGACCGTCGGGCTGTCGTGGACGGCGCTGCTCGGCTTCGTCAGAATCGCCACCAACC
CGTCGATCCTGCCCCGCCCGCTCCGTCCGGCCGAGGCCTTCGACATCATCGACGCGTGGCTGGCGTCCCCCGCCGCCGTC
GTCGTCGAACCGACCTCCCGGCATCTGGCGATCCTCCGCGGACTGCTCACCGAATTCGGAACGGCCGGAAATCTGACCAG
CGACGCGCACCTGGCCGCACTGGCCGTCGAGTACGGCGGCGTCGTGGTGACCTTCGACCGCGACTTCGCCCGGTTCGGCG
TCGACACCGTCACGCCGGCCGGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT209757 WP_000584499.1 NZ_CP079715:c200488-200237 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT209757 NZ_CP104302:c113592-113341 [Mycolicibacterium brumae]
ATGCGGACGACGGTCACCCTGGACTCCGATGTGGAGGTGCGGCTGCAGGCTCTGATGCGCGATCGTGGTCTGTCCTTCAA
GGAAGCCATCAACACCGCGCTGCGGGCGGGCTTGAACGCCGGCGGGCCGGTTGACGTCGCATTTCCGGTCTACGACATGG
GAACGCCGACCGTGGACCTCACCCACGCCGGTCGGCTCGCCGCGGCGCTGGAGGACGAGGAGATCGCCCGCAAGTTGGCA
TCCGGCCGATGA
ATGCGGACGACGGTCACCCTGGACTCCGATGTGGAGGTGCGGCTGCAGGCTCTGATGCGCGATCGTGGTCTGTCCTTCAA
GGAAGCCATCAACACCGCGCTGCGGGCGGGCTTGAACGCCGGCGGGCCGGTTGACGTCGCATTTCCGGTCTACGACATGG
GAACGCCGACCGTGGACCTCACCCACGCCGGTCGGCTCGCCGCGGCGCTGGAGGACGAGGAGATCGCCCGCAAGTTGGCA
TCCGGCCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|