Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
Location | 4066856..4067453 | Replicon | chromosome |
Accession | NZ_CP079668 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC28_CMC387MPCH |
Toxin (Protein)
Gene name | higB | Uniprot ID | R4YIC5 |
Locus tag | KW561_RS19865 | Protein ID | WP_004142563.1 |
Coordinates | 4067136..4067453 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | R4YH91 |
Locus tag | KW561_RS19860 | Protein ID | WP_004142561.1 |
Coordinates | 4066856..4067143 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KW561_RS19830 (4062936) | 4062936..4063184 | + | 249 | WP_002893037.1 | DUF1158 domain-containing protein | - |
KW561_RS19835 (4063202) | 4063202..4063543 | - | 342 | WP_002893035.1 | RamA family antibiotic efflux transcriptional regulator | - |
KW561_RS19840 (4063574) | 4063574..4064689 | - | 1116 | WP_020316605.1 | MBL fold metallo-hydrolase | - |
KW561_RS19845 (4064869) | 4064869..4065450 | + | 582 | WP_043906838.1 | TetR/AcrR family transcriptional regulator | - |
KW561_RS19850 (4065450) | 4065450..4065818 | + | 369 | WP_004142557.1 | MmcQ/YjbR family DNA-binding protein | - |
KW561_RS19855 (4065938) | 4065938..4066588 | + | 651 | Protein_3913 | oxygen-insensitive NAD(P)H nitroreductase | - |
KW561_RS19860 (4066856) | 4066856..4067143 | - | 288 | WP_004142561.1 | helix-turn-helix transcriptional regulator | Antitoxin |
KW561_RS19865 (4067136) | 4067136..4067453 | - | 318 | WP_004142563.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KW561_RS19870 (4067638) | 4067638..4068681 | - | 1044 | WP_004178895.1 | DUF2157 domain-containing protein | - |
KW561_RS19875 (4069348) | 4069348..4070214 | - | 867 | WP_004178894.1 | helix-turn-helix transcriptional regulator | - |
KW561_RS19880 (4070323) | 4070323..4071750 | + | 1428 | WP_004176980.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12110.39 Da Isoelectric Point: 11.2767
>T209669 WP_004142563.1 NZ_CP079668:c4067453-4067136 [Klebsiella pneumoniae subsp. pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE
Download Length: 318 bp
>T209669 NZ_CP104209:2560016-2560300 [Empedobacter stercoris]
ATGGAAACATCAAAATTTGATATAGCCGATTATTTAGATAGTAATGAAATGATTGCTGAATACTTAAATGCAGTCTTAGA
AGATGGTAATGAAAATGAAATCATCACTGCTATTGGAAACATTGCAAAAGCAATTGGAATGACTAAAATAGCAGAAGAAA
CAGGTCTTAGTCGTCCAAGTTTATATAAAGCTTTATCTGATGGTTCAAAACCTCAATTTGGAACTATAATGAAAGTTTTA
AAAGCTGTGGGAGGACAAATACAAGTAAATCCTGTTCAAGCTTAA
ATGGAAACATCAAAATTTGATATAGCCGATTATTTAGATAGTAATGAAATGATTGCTGAATACTTAAATGCAGTCTTAGA
AGATGGTAATGAAAATGAAATCATCACTGCTATTGGAAACATTGCAAAAGCAATTGGAATGACTAAAATAGCAGAAGAAA
CAGGTCTTAGTCGTCCAAGTTTATATAAAGCTTTATCTGATGGTTCAAAACCTCAATTTGGAACTATAATGAAAGTTTTA
AAAGCTGTGGGAGGACAAATACAAGTAAATCCTGTTCAAGCTTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10771.46 Da Isoelectric Point: 10.2212
>AT209669 WP_004142561.1 NZ_CP079668:c4067143-4066856 [Klebsiella pneumoniae subsp. pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY
Download Length: 288 bp
>AT209669 NZ_CP104209:2559710-2559868 [Empedobacter stercoris]
ATGTACTTTATTGAAAAAACTACTGATTTTGATAAATGGTTTCGTAAGTTAAAAGACTTACGAGCAAAGGCTAAAATTTT
AGTTAGAATTCAAAAATTAGAAAAAGAAGAACACTTTGGAGATTGTGAACCTGTTGGCAATGGAATTCGAGAATTATAG
ATGTACTTTATTGAAAAAACTACTGATTTTGATAAATGGTTTCGTAAGTTAAAAGACTTACGAGCAAAGGCTAAAATTTT
AGTTAGAATTCAAAAATTAGAAAAAGAAGAACACTTTGGAGATTGTGAACCTGTTGGCAATGGAATTCGAGAATTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M5MXH8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0S3DIQ1 |