Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-YefM |
| Location | 1478535..1479037 | Replicon | chromosome |
| Accession | NC_004757 | ||
| Organism | Nitrosomonas europaea ATCC 19718 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | Q82UW6 |
| Locus tag | ALW85_RS07055 | Protein ID | WP_011111929.1 |
| Coordinates | 1478535..1478795 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A837X5B7 |
| Locus tag | ALW85_RS07060 | Protein ID | WP_041356748.1 |
| Coordinates | 1478795..1479037 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ALW85_RS07020 (NE1345) | 1474137..1474397 | - | 261 | WP_011111923.1 | Txe/YoeB family addiction module toxin | - |
| ALW85_RS07025 (NE1346) | 1474400..1474660 | - | 261 | WP_041356746.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| ALW85_RS07030 (NE1347) | 1474936..1475978 | + | 1043 | Protein_1357 | IS481 family transposase | - |
| ALW85_RS07035 (NE1349) | 1476105..1476500 | - | 396 | WP_011111927.1 | type II toxin-antitoxin system VapC family toxin | - |
| ALW85_RS07040 (NE1350) | 1476508..1476753 | - | 246 | WP_011111928.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| ALW85_RS07050 (NE1351) | 1477435..1478478 | + | 1044 | WP_011110809.1 | IS481 family transposase | - |
| ALW85_RS07055 (NE1352) | 1478535..1478795 | - | 261 | WP_011111929.1 | Txe/YoeB family addiction module toxin | Toxin |
| ALW85_RS07060 (RK28_RS07055) | 1478795..1479037 | - | 243 | WP_041356748.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ALW85_RS07065 (RK28_RS07060) | 1479355..1479621 | + | 267 | WP_041357169.1 | hypothetical protein | - |
| ALW85_RS07070 (NE1353) | 1479618..1479917 | + | 300 | WP_011111930.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ALW85_RS07075 (NE1354) | 1480079..1480357 | - | 279 | Protein_1365 | XRE family transcriptional regulator | - |
| ALW85_RS14305 | 1480354..1480452 | - | 99 | WP_198407841.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ALW85_RS14310 | 1480424..1480645 | - | 222 | WP_041356749.1 | DUF2442 domain-containing protein | - |
| ALW85_RS07085 (RK28_RS07080) | 1480651..1480809 | - | 159 | WP_198407842.1 | DUF4160 domain-containing protein | - |
| ALW85_RS07090 (NE1355) | 1480914..1481234 | - | 321 | WP_011111932.1 | putative addiction module antidote protein | - |
| ALW85_RS07095 (NE1356) | 1481227..1481535 | - | 309 | WP_041357171.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ALW85_RS07105 (NE1358) | 1482114..1482425 | + | 312 | WP_198407843.1 | HigA family addiction module antidote protein | - |
| ALW85_RS07110 (NE1360) | 1482500..1483081 | - | 582 | WP_041356750.1 | RloB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1475610..1500344 | 24734 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10118.77 Da Isoelectric Point: 10.1619
>T20965 WP_011111929.1 NC_004757:c1478795-1478535 [Nitrosomonas europaea ATCC 19718]
MWELRYTHQAQKDAKKLASSGLKDKAEELLAVVRNNPYQTPPPYEKLVGDLAGACSRRINIQHRLVYQVLERERIVKVLR
MWTHYV
MWELRYTHQAQKDAKKLASSGLKDKAEELLAVVRNNPYQTPPPYEKLVGDLAGACSRRINIQHRLVYQVLERERIVKVLR
MWTHYV
Download Length: 261 bp
>T20965 NC_004757:c1478795-1478535 [Nitrosomonas europaea ATCC 19718]
ATGTGGGAGCTGCGATATACCCATCAAGCGCAAAAGGATGCAAAAAAGCTGGCATCGTCTGGGCTTAAAGATAAGGCAGA
GGAGTTGTTAGCGGTTGTGAGGAATAATCCGTACCAAACCCCACCCCCCTATGAAAAGCTGGTTGGTGATTTGGCTGGAG
CCTGTTCACGCCGTATCAACATCCAGCACAGGCTCGTGTATCAGGTGTTGGAGCGGGAGAGGATAGTAAAGGTTTTGCGT
ATGTGGACTCATTATGTGTAG
ATGTGGGAGCTGCGATATACCCATCAAGCGCAAAAGGATGCAAAAAAGCTGGCATCGTCTGGGCTTAAAGATAAGGCAGA
GGAGTTGTTAGCGGTTGTGAGGAATAATCCGTACCAAACCCCACCCCCCTATGAAAAGCTGGTTGGTGATTTGGCTGGAG
CCTGTTCACGCCGTATCAACATCCAGCACAGGCTCGTGTATCAGGTGTTGGAGCGGGAGAGGATAGTAAAGGTTTTGCGT
ATGTGGACTCATTATGTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9010.25 Da Isoelectric Point: 4.2340
>AT20965 WP_041356748.1 NC_004757:c1479037-1478795 [Nitrosomonas europaea ATCC 19718]
MAILNATEARARLYALIDEAAETHQPIVIKGKRSSAVLLSEEDWNAINETLYLVSIPGMRESIMEGMKTDVDECSRELDW
MAILNATEARARLYALIDEAAETHQPIVIKGKRSSAVLLSEEDWNAINETLYLVSIPGMRESIMEGMKTDVDECSRELDW
Download Length: 243 bp
>AT20965 NC_004757:c1479037-1478795 [Nitrosomonas europaea ATCC 19718]
ATGGCAATACTAAACGCAACAGAAGCAAGAGCGAGGTTGTACGCCTTAATTGATGAGGCCGCAGAAACACACCAGCCTAT
TGTGATTAAGGGAAAAAGGTCAAGTGCGGTGCTTTTATCGGAGGAAGACTGGAACGCTATCAACGAGACGCTTTACTTGG
TTTCTATCCCGGGAATGCGCGAATCCATTATGGAGGGTATGAAAACTGATGTGGATGAGTGCAGTAGGGAATTGGATTGG
TAA
ATGGCAATACTAAACGCAACAGAAGCAAGAGCGAGGTTGTACGCCTTAATTGATGAGGCCGCAGAAACACACCAGCCTAT
TGTGATTAAGGGAAAAAGGTCAAGTGCGGTGCTTTTATCGGAGGAAGACTGGAACGCTATCAACGAGACGCTTTACTTGG
TTTCTATCCCGGGAATGCGCGAATCCATTATGGAGGGTATGAAAACTGATGTGGATGAGTGCAGTAGGGAATTGGATTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q82UW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A837X5B7 |