Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 347607..348193 Replicon chromosome
Accession NZ_CP079629
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KW554_RS01590 Protein ID WP_002920800.1
Coordinates 347825..348193 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KW554_RS01585 Protein ID WP_004174006.1
Coordinates 347607..347828 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW554_RS01565 (343764) 343764..344690 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KW554_RS01570 (344687) 344687..345964 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
KW554_RS01575 (345961) 345961..346728 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KW554_RS01580 (346730) 346730..347443 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KW554_RS01585 (347607) 347607..347828 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KW554_RS01590 (347825) 347825..348193 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KW554_RS01595 (348466) 348466..349782 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KW554_RS01600 (349889) 349889..350776 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KW554_RS01605 (350773) 350773..351618 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KW554_RS01610 (351620) 351620..352690 + 1071 WP_043906884.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 344687..353427 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T209546 WP_002920800.1 NZ_CP079629:347825-348193 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T209546 NZ_CP104129:c237068-236622 [Sinorhizobium sp. M103]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTAATCGATCCGGGCCATGTTGCCCATGACGATGCGCACGAATG
GTTCGCGGCGACGGGTCAGACCGCGTGGGCTACCTGCCCCATTACCGAAAACGGCGTCATCCGGATTGTCGGCAATCCCA
AATATCCGAATTCTCCCGGTTCACCGTCACTCGTGATGGAGATCGTCGGCAAAATGCGGTCGCTCCCCGGTCACAGTTTT
TGGCCGGACGATGTGAGCCTTGTCGGCTCAGGTGATATCGCTCCCACGAAAATCCTAACTTCGGGGCAGGTAACTGATAC
CTATCTCCTTGCGCTCGCCAAGGCGCGTGGGGGGCAACTGGCGACATTCGATCGCAAGCTCTCAGCAGCGGCGGTCACGA
GGGGTAATTCTGCCTTGCACCTGATCACTGCAACTCGGGTTCGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT209546 WP_004174006.1 NZ_CP079629:347607-347828 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT209546 NZ_CP104129:c237292-237065 [Sinorhizobium sp. M103]
ATGAGAACGACCCTGGCAATCGACGACGATGTACTGATCGCCGCAAAGGCGATGGCAGCCCAGCAGCACCGGAGCGTCGG
CGAAGTCATTTCCGAACTGGCTAGACGTTCTTTGCGCAGACCGCGCAGCAGCGGCGAGCGCAATGGAATTCCTCTCTTAT
CACCTCAGCCGGATGCTCCGCCAGTGACGCTCGAGATCGTCAACGCCTTGCGTGACGAACTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References