Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 520813..521406 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ALW85_RS02545 Protein ID WP_041357019.1
Coordinates 521128..521406 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ALW85_RS02540 Protein ID WP_011111112.1
Coordinates 520813..521118 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALW85_RS02510 (NE0475) 516404..516625 + 222 WP_011111106.1 ribbon-helix-helix protein, CopG family -
ALW85_RS02515 (NE0476) 516603..516857 + 255 WP_011111107.1 type II toxin-antitoxin system RelE/ParE family toxin -
ALW85_RS13875 517180..517371 + 192 WP_143023752.1 type II toxin-antitoxin system RelE/ParE family toxin -
ALW85_RS02520 (NE0477) 517316..519226 - 1911 WP_011111108.1 ATP-binding cassette domain-containing protein -
ALW85_RS02525 (NE0478) 519527..519760 + 234 WP_011111109.1 antitoxin -
ALW85_RS02530 (NE0479) 519760..520161 + 402 WP_011111110.1 type II toxin-antitoxin system VapC family toxin -
ALW85_RS02535 (NE0480) 520320..520748 + 429 WP_011111111.1 hypothetical protein -
ALW85_RS02540 (NE0481) 520813..521118 - 306 WP_011111112.1 HigA family addiction module antidote protein Antitoxin
ALW85_RS02545 (NE0482) 521128..521406 - 279 WP_041357019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ALW85_RS02550 (NE0483) 521508..522863 + 1356 WP_011111114.1 ABC transporter ATP-binding protein -
ALW85_RS02555 (NE0484) 522860..526066 + 3207 WP_011111115.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-87)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10587.99 Da        Isoelectric Point: 5.0911

>T20954 WP_041357019.1 NC_004757:c521406-521128 [Nitrosomonas europaea ATCC 19718]
MIQSFRCKSTQAMFEGECPQRFSAIQAVAERKLAQLEAAQTLDFLRSPPGNRLEKLAGDREGQWSIRINAQWRICFTWSD
LDPADVEIVDYH

Download         Length: 279 bp

>T20954 NC_004757:c521406-521128 [Nitrosomonas europaea ATCC 19718]
ATGATCCAGTCTTTTCGATGTAAGAGTACTCAAGCAATGTTTGAGGGTGAATGTCCTCAGCGTTTTAGTGCCATCCAAGC
TGTGGCTGAACGTAAGCTGGCACAATTGGAAGCGGCACAAACACTTGATTTTTTGCGCTCTCCACCAGGAAATCGGCTGG
AAAAACTGGCTGGCGACCGGGAAGGTCAATGGAGCATTCGTATCAACGCACAATGGCGTATATGCTTTACTTGGTCTGAT
CTCGATCCTGCCGATGTAGAGATTGTTGATTATCATTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11398.04 Da        Isoelectric Point: 8.6756

>AT20954 WP_011111112.1 NC_004757:c521118-520813 [Nitrosomonas europaea ATCC 19718]
MTRPVNRMRAVHPGEVLREDFLIPAGISVNALAIALSVPATRIHEIVKERRAVTADTAERLAHYFGGDAASWLALQASYD
LKTLPTRDEIERRVQRREEHV

Download         Length: 306 bp

>AT20954 NC_004757:c521118-520813 [Nitrosomonas europaea ATCC 19718]
ATGACTAGACCTGTAAACCGCATGCGTGCCGTCCATCCCGGGGAAGTGCTGCGTGAAGATTTTCTGATTCCAGCCGGGAT
AAGTGTCAACGCTCTGGCAATTGCCTTGAGTGTGCCAGCCACCCGCATTCATGAAATCGTCAAGGAGCGGCGCGCCGTTA
CCGCTGATACTGCTGAGCGGCTGGCGCATTATTTCGGGGGTGATGCCGCTTCCTGGCTTGCTCTGCAGGCCAGTTACGAT
CTGAAAACACTGCCCACGCGCGATGAAATTGAACGCCGCGTGCAAAGGCGTGAAGAACACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References