Detailed information of TA system TA209471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1272218..1272732
• Replicon: chromosome
• Accession: NZ_CP079236
• Organism: Bifidobacterium pseudocatenulatum strain YIT11027

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KYE75_RS05570
• Protein ID: WP_055054685.1
• Coordinates: 1272478..1272732 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KYE75_RS05565
• Protein ID: WP_065438750.1
• Coordinates: 1272218..1272478 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYE75_RS05560 (KYE75_05550)	1271094..1271411	+	318	WP_065440803.1	hypothetical protein	-
KYE75_RS05565 (KYE75_05555)	1272218..1272478	+	261	WP_065438750.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KYE75_RS05570 (KYE75_05560)	1272478..1272732	+	255	WP_055054685.1	Txe/YoeB family addiction module toxin	Toxin
KYE75_RS11120	1272719..1272847	+	129	WP_259297793.1	hypothetical protein	-
KYE75_RS05575 (KYE75_05565)	1272935..1273831	-	897	WP_065438748.1	Fic family protein	-
KYE75_RS05580 (KYE75_05570)	1273909..1274217	+	309	WP_147324816.1	hypothetical protein	-
KYE75_RS05585 (KYE75_05575)	1274249..1276444	-	2196	WP_226845991.1	type IA DNA topoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1234396..1278733	44337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10013.51 Da
• Isoelectric Point: 7.9920

>T209471 WP_055054685.1 NZ_CP079236:1272478-1272732 [Bifidobacterium pseudocatenulatum]
IMLRWTDDAWNDYLYWQVQDKKTLKRVNALIRDAMRSPFAGLGKPEPLKWELQGAWSRRIDSANRLVYMIEDGDLCILSV
RDHY

Nucleotide

• Length: 255 bp

>T209471 NZ_CP104114:c989388-989110 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9728.98 Da
• Isoelectric Point: 4.7241

>AT209471 WP_065438750.1 NZ_CP079236:1272218-1272478 [Bifidobacterium pseudocatenulatum]
MVTAVAYTNFRKDLKSYLRRVNDDADMLLITNKDPGDNVVVMSADDYDSLMETLRVYQNPGLFDKVRRGMAQVRSGSTDL
HDLVGE

Nucleotide

• Length: 261 bp

>AT209471 NZ_CP104114:c989651-989391 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA