Detailed information of TA system TA209461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2280183..2280691
• Replicon: chromosome
• Accession: NZ_CP079203
• Organism: Sphingomonas sanguinis strain NP2-R2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KV697_RS10565
• Protein ID: WP_056435835.1
• Coordinates: 2280425..2280691 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KV697_RS10560
• Protein ID: WP_219018144.1
• Coordinates: 2280183..2280428 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KV697_RS10520 (KV697_10520)	2275317..2276150	+	834	WP_257575857.1	sterol desaturase family protein	-
KV697_RS10525 (KV697_10525)	2276053..2276436	+	384	WP_257575255.1	DUF2141 domain-containing protein	-
KV697_RS10530 (KV697_10530)	2276509..2277393	+	885	WP_219018138.1	MipA/OmpV family protein	-
KV697_RS10535 (KV697_10535)	2277527..2278039	-	513	WP_219018139.1	hypothetical protein	-
KV697_RS10540 (KV697_10540)	2278103..2278546	+	444	WP_219018140.1	DUF1810 domain-containing protein	-
KV697_RS10545 (KV697_10545)	2278567..2278941	-	375	WP_219018141.1	hypothetical protein	-
KV697_RS10550 (KV697_10550)	2279052..2279747	+	696	WP_219018142.1	uracil-DNA glycosylase	-
KV697_RS10555 (KV697_10555)	2279832..2280143	+	312	WP_219018143.1	alkylphosphonate utilization protein	-
KV697_RS10560 (KV697_10560)	2280183..2280428	+	246	WP_219018144.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KV697_RS10565 (KV697_10565)	2280425..2280691	+	267	WP_056435835.1	Txe/YoeB family addiction module toxin	Toxin
KV697_RS10570 (KV697_10570)	2280701..2281318	-	618	WP_219018145.1	hypothetical protein	-
KV697_RS10575 (KV697_10575)	2281334..2283247	-	1914	WP_219018146.1	phosphomethylpyrimidine synthase ThiC	-
KV697_RS10580 (KV697_10580)	2283547..2284581	-	1035	WP_219018147.1	ferritin-like domain-containing protein	-
KV697_RS10585 (KV697_10585)	2284616..2285599	-	984	WP_219018148.1	ferritin-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.69 Da
• Isoelectric Point: 8.2963

>T209461 WP_056435835.1 NZ_CP079203:2280425-2280691 [Sphingomonas sanguinis]
VKVAFWPTAWDDYRHWQEHDAKLCDKLNALIEECRRHPFKGTGKPEPLGGNLSGWWSRRISHEHRLVYRVAGSGDEQVLQ
VAQCRYHY

Nucleotide

• Length: 267 bp

>T209461 NZ_CP104112:c3659185-3658778 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8833.99 Da
• Isoelectric Point: 4.4155

>AT209461 WP_219018144.1 NZ_CP079203:2280183-2280428 [Sphingomonas sanguinis]
MQAVSYSEARENLKAMIDKVVADRAPVAITRQRGEGAVLISASEWASIEETLYLLQSPKNAERLLDAVRGFEAGDEGVPF
P

Nucleotide

• Length: 246 bp

>AT209461 NZ_CP104112:c3659432-3659166 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA