Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 1038791..1039377 | Replicon | chromosome |
Accession | NZ_CP079131 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC04_AI1235MC |
Toxin (Protein)
Gene name | doc | Uniprot ID | W8VD46 |
Locus tag | KWY69_RS04805 | Protein ID | WP_002920800.1 |
Coordinates | 1039009..1039377 (+) | Length | 123 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | W9B1V1 |
Locus tag | KWY69_RS04800 | Protein ID | WP_004174006.1 |
Coordinates | 1038791..1039012 (+) | Length | 74 a.a. |
Genomic Context
Location: 1034948..1035874 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Type: Others
Protein ID: WP_002920807.1
Location: 1035871..1037148 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Type: Others
Protein ID: WP_004174005.1
Location: 1037145..1037912 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Type: Others
Protein ID: WP_002920803.1
Location: 1037914..1038627 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Type: Others
Protein ID: WP_004145133.1
Location: 1038791..1039012 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 1039009..1039377 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Type: Toxin
Protein ID: WP_002920800.1
Location: 1039650..1040966 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Type: Others
Protein ID: WP_004174008.1
Location: 1041073..1041960 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Type: Others
Protein ID: WP_002920792.1
Location: 1041957..1042802 (846 bp)
Type: Others
Protein ID: WP_004181473.1
Type: Others
Protein ID: WP_004181473.1
Location: 1042804..1043874 (1071 bp)
Type: Others
Protein ID: WP_043906884.1
Type: Others
Protein ID: WP_043906884.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KWY69_RS04780 (1034948) | 1034948..1035874 | + | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
KWY69_RS04785 (1035871) | 1035871..1037148 | + | 1278 | WP_004174005.1 | branched chain amino acid ABC transporter permease LivM | - |
KWY69_RS04790 (1037145) | 1037145..1037912 | + | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
KWY69_RS04795 (1037914) | 1037914..1038627 | + | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
KWY69_RS04800 (1038791) | 1038791..1039012 | + | 222 | WP_004174006.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KWY69_RS04805 (1039009) | 1039009..1039377 | + | 369 | WP_002920800.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
KWY69_RS04810 (1039650) | 1039650..1040966 | + | 1317 | WP_004174008.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
KWY69_RS04815 (1041073) | 1041073..1041960 | + | 888 | WP_002920792.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
KWY69_RS04820 (1041957) | 1041957..1042802 | + | 846 | WP_004181473.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
KWY69_RS04825 (1042804) | 1042804..1043874 | + | 1071 | WP_043906884.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1035871..1044611 | 8740 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.92 Da Isoelectric Point: 8.6410
>T209277 WP_002920800.1 NZ_CP079131:1039009-1039377 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T209277 NZ_CP104006:621902-622273 [Yersinia alsatica]
ATGAAACCAAACCCCACAACAGCGGGTGCATTACCCGTGCCTGCTATTTATCAACAACTGCTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATTGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTAAGCAAAGGCGATATCGTGCGGGCTCGCCAGGCTTCGGGCTTGTGGCGTGCTCATTTTCCGCCCACGTT
GCTGTACCCAACCGAATCCCTCAATCCTATTCCACAGAGACCGTTAACATGA
ATGAAACCAAACCCCACAACAGCGGGTGCATTACCCGTGCCTGCTATTTATCAACAACTGCTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATTGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTAAGCAAAGGCGATATCGTGCGGGCTCGCCAGGCTTCGGGCTTGTGGCGTGCTCATTTTCCGCCCACGTT
GCTGTACCCAACCGAATCCCTCAATCCTATTCCACAGAGACCGTTAACATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.15 Da Isoelectric Point: 4.7769
>AT209277 WP_004174006.1 NZ_CP079131:1038791-1039012 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT209277 NZ_CP104006:622270-622638 [Yersinia alsatica]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGACATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACGCATCTGCATTTTCTGAGCGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCACTCAGGCTCTTG
ATGCGGTATTCCCCGCGCTGATAACCAAACTAGAATCGCAGCTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGCGAATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTATATTGCGATTTATCA
GGAACTGTCTGCGTTATTTTCAGAAGGAGGAGGGCCACCTGACGTTTAA
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGACATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACGCATCTGCATTTTCTGAGCGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCACTCAGGCTCTTG
ATGCGGTATTCCCCGCGCTGATAACCAAACTAGAATCGCAGCTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGCGAATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTATATTGCGATTTATCA
GGAACTGTCTGCGTTATTTTCAGAAGGAGGAGGGCCACCTGACGTTTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GUD1 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E5YJY7 |