Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1038791..1039377 Replicon chromosome
Accession NZ_CP079131
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC04_AI1235MC

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KWY69_RS04805 Protein ID WP_002920800.1
Coordinates 1039009..1039377 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KWY69_RS04800 Protein ID WP_004174006.1
Coordinates 1038791..1039012 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY69_RS04780 (1034948) 1034948..1035874 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KWY69_RS04785 (1035871) 1035871..1037148 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
KWY69_RS04790 (1037145) 1037145..1037912 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KWY69_RS04795 (1037914) 1037914..1038627 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KWY69_RS04800 (1038791) 1038791..1039012 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KWY69_RS04805 (1039009) 1039009..1039377 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KWY69_RS04810 (1039650) 1039650..1040966 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KWY69_RS04815 (1041073) 1041073..1041960 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KWY69_RS04820 (1041957) 1041957..1042802 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KWY69_RS04825 (1042804) 1042804..1043874 + 1071 WP_043906884.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1035871..1044611 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T209277 WP_002920800.1 NZ_CP079131:1039009-1039377 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T209277 NZ_CP104006:621902-622273 [Yersinia alsatica]
ATGAAACCAAACCCCACAACAGCGGGTGCATTACCCGTGCCTGCTATTTATCAACAACTGCTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATTGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTAAGCAAAGGCGATATCGTGCGGGCTCGCCAGGCTTCGGGCTTGTGGCGTGCTCATTTTCCGCCCACGTT
GCTGTACCCAACCGAATCCCTCAATCCTATTCCACAGAGACCGTTAACATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT209277 WP_004174006.1 NZ_CP079131:1038791-1039012 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT209277 NZ_CP104006:622270-622638 [Yersinia alsatica]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGACATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACGCATCTGCATTTTCTGAGCGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCACTCAGGCTCTTG
ATGCGGTATTCCCCGCGCTGATAACCAAACTAGAATCGCAGCTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGCGAATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTATATTGCGATTTATCA
GGAACTGTCTGCGTTATTTTCAGAAGGAGGAGGGCCACCTGACGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References