Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1038791..1039377 Replicon chromosome
Accession NZ_CP079131
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC04_AI1235MC

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KWY69_RS04805 Protein ID WP_002920800.1
Coordinates 1039009..1039377 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KWY69_RS04800 Protein ID WP_004174006.1
Coordinates 1038791..1039012 (+) Length 74 a.a.

Genomic Context


KWY69_RS04780KWY69_RS04785KWY69_RS04790KWY69_RS04795KWY69_RS04800KWY69_RS04805KWY69_RS04810KWY69_RS04815KWY69_RS04820KWY69_RS04825
Location: 1034948..1035874 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 1035871..1037148 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 1037145..1037912 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 1037914..1038627 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 1038791..1039012 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 1039009..1039377 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 1039650..1040966 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Location: 1041073..1041960 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 1041957..1042802 (846 bp)
Type: Others
Protein ID: WP_004181473.1
Location: 1042804..1043874 (1071 bp)
Type: Others
Protein ID: WP_043906884.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KWY69_RS04780 (1034948)1034948..1035874+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
KWY69_RS04785 (1035871)1035871..1037148+1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
KWY69_RS04790 (1037145)1037145..1037912+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
KWY69_RS04795 (1037914)1037914..1038627+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
KWY69_RS04800 (1038791)1038791..1039012+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KWY69_RS04805 (1039009)1039009..1039377+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
KWY69_RS04810 (1039650)1039650..1040966+1317WP_004174008.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
KWY69_RS04815 (1041073)1041073..1041960+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
KWY69_RS04820 (1041957)1041957..1042802+846WP_004181473.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
KWY69_RS04825 (1042804)1042804..1043874+1071WP_043906884.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1035871..10446118740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T209277 WP_002920800.1 NZ_CP079131:1039009-1039377 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T209277 NZ_CP104006:621902-622273 [Yersinia alsatica]
ATGAAACCAAACCCCACAACAGCGGGTGCATTACCCGTGCCTGCTATTTATCAACAACTGCTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATTGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTAAGCAAAGGCGATATCGTGCGGGCTCGCCAGGCTTCGGGCTTGTGGCGTGCTCATTTTCCGCCCACGTT
GCTGTACCCAACCGAATCCCTCAATCCTATTCCACAGAGACCGTTAACATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT209277 WP_004174006.1 NZ_CP079131:1038791-1039012 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT209277 NZ_CP104006:622270-622638 [Yersinia alsatica]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGACATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACGCATCTGCATTTTCTGAGCGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCACTCAGGCTCTTG
ATGCGGTATTCCCCGCGCTGATAACCAAACTAGAATCGCAGCTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGCGAATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTATATTGCGATTTATCA
GGAACTGTCTGCGTTATTTTCAGAAGGAGGAGGGCCACCTGACGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References