Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3267734..3268242 Replicon chromosome
Accession NZ_CP079114
Organism Streptomyces sp. WY228

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KV381_RS14110 Protein ID WP_030633191.1
Coordinates 3267982..3268242 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID V6U6C9
Locus tag KV381_RS14105 Protein ID WP_006125193.1
Coordinates 3267734..3267985 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KV381_RS14085 (KV381_14085) 3262965..3264791 - 1827 WP_030086318.1 ABC-F family ATP-binding cassette domain-containing protein -
KV381_RS14090 (KV381_14090) 3264940..3265314 + 375 WP_103536636.1 hypothetical protein -
KV381_RS14095 (KV381_14095) 3265409..3266548 + 1140 WP_218785321.1 hypothetical protein -
KV381_RS14100 (KV381_14100) 3266545..3267627 + 1083 WP_218785322.1 hypothetical protein -
KV381_RS14105 (KV381_14105) 3267734..3267985 + 252 WP_006125193.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KV381_RS14110 (KV381_14110) 3267982..3268242 + 261 WP_030633191.1 Txe/YoeB family addiction module toxin Toxin
KV381_RS14115 (KV381_14115) 3268246..3269583 - 1338 WP_030633193.1 acyltransferase -
KV381_RS14120 (KV381_14120) 3269874..3270605 + 732 WP_193463092.1 hypothetical protein -
KV381_RS14125 (KV381_14125) 3270607..3271509 - 903 WP_193463214.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
KV381_RS14130 (KV381_14130) 3271515..3272390 - 876 WP_086779802.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10299.61 Da        Isoelectric Point: 9.5031

>T209231 WP_030633191.1 NZ_CP079114:3267982-3268242 [Streptomyces sp. WY228]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFHGYWSRRITDEHRLISKVVGDEVRIAAC
RYHYGN

Download         Length: 261 bp

>T209231 NZ_CP103972:c4869730-4869623 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9272.34 Da        Isoelectric Point: 4.4118

>AT209231 WP_006125193.1 NZ_CP079114:3267734-3267985 [Streptomyces sp. WY228]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLESGGGTVQE
LAE

Download         Length: 252 bp

>AT209231 NZ_CP103972:4869778-4869844 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6U6C9

References