Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1051017..1051527 Replicon chromosome
Accession NZ_CP079110
Organism Nosocomiicoccus ampullae strain DSM 19163

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KPF49_RS05370 Protein ID WP_183672623.1
Coordinates 1051017..1051286 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KPF49_RS05375 Protein ID WP_183672622.1
Coordinates 1051279..1051527 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPF49_RS08070 1046471..1046596 - 126 WP_246562818.1 type II toxin-antitoxin system RelE/ParE family toxin -
KPF49_RS05335 (KPF49_05335) 1046667..1046831 - 165 WP_183672630.1 DUF6290 family protein -
KPF49_RS05340 (KPF49_05340) 1047141..1047923 - 783 WP_183672629.1 ABC transporter permease -
KPF49_RS05345 (KPF49_05345) 1047910..1048647 - 738 WP_183672628.1 ABC transporter ATP-binding protein -
KPF49_RS05350 (KPF49_05350) 1048665..1049162 - 498 WP_183672627.1 hypothetical protein -
KPF49_RS05355 (KPF49_05355) 1049201..1049680 - 480 WP_183672626.1 hypothetical protein -
KPF49_RS05360 (KPF49_05360) 1050008..1050145 - 138 WP_183672625.1 hypothetical protein -
KPF49_RS05365 (KPF49_05365) 1050431..1050691 - 261 WP_183672624.1 hypothetical protein -
KPF49_RS05370 (KPF49_05370) 1051017..1051286 - 270 WP_183672623.1 Txe/YoeB family addiction module toxin Toxin
KPF49_RS05375 (KPF49_05375) 1051279..1051527 - 249 WP_183672622.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KPF49_RS05380 (KPF49_05380) 1051654..1051935 - 282 WP_219490070.1 type II toxin-antitoxin system PemK/MazF family toxin -
KPF49_RS05385 (KPF49_05385) 1052480..1052749 + 270 WP_183672620.1 hypothetical protein -
KPF49_RS08075 1053094..1053280 - 187 Protein_1063 hypothetical protein -
KPF49_RS05390 (KPF49_05390) 1053306..1053803 - 498 WP_183672619.1 hypothetical protein -
KPF49_RS08125 (KPF49_05395) 1053940..1054581 - 642 WP_276516288.1 transglycosylase family protein -
KPF49_RS05400 (KPF49_05400) 1054952..1055692 - 741 WP_183672617.1 7-carboxy-7-deazaguanine synthase QueE -
KPF49_RS05405 (KPF49_05405) 1055692..1056066 - 375 WP_183672616.1 6-carboxytetrahydropterin synthase QueD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10566.37 Da        Isoelectric Point: 10.3625

>T209230 WP_183672623.1 NZ_CP079110:c1051286-1051017 [Nosocomiicoccus ampullae]
MSKLLITFSTEAFEDYKEWQIQDKKTLKKINQLIKSIEREGVLSGIGKPEKLKGNLSGWYSRRITQEHRLVYKIDKRSIM
IASCKYHYK

Download         Length: 270 bp

>T209230 NZ_CP103972:c4057668-4057450 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9604.59 Da        Isoelectric Point: 4.7469

>AT209230 WP_183672622.1 NZ_CP079110:c1051527-1051279 [Nosocomiicoccus ampullae]
MSVETYSNARKNFRQLINQVNDNSEVITITTNEHNAVLMSESDYNSIMETFYLQKNPYNNEHLKRSISQFDKGETVKVQI
DE

Download         Length: 249 bp

>AT209230 NZ_CP103972:c4058068-4057694 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References