Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2555575..2556155 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KW115_RS12555 Protein ID WP_218806058.1
Coordinates 2555877..2556155 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KW115_RS12550 Protein ID WP_218806057.1
Coordinates 2555575..2555877 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS12520 (KW115_12520) 2550891..2553245 - 2355 WP_218806051.1 DUF927 domain-containing protein -
KW115_RS12525 (KW115_12525) 2553505..2553759 - 255 WP_218806052.1 hypothetical protein -
KW115_RS12530 (KW115_12530) 2553752..2554039 - 288 WP_218806053.1 hypothetical protein -
KW115_RS12535 (KW115_12535) 2554350..2554619 + 270 WP_218806054.1 DUF1640 domain-containing protein -
KW115_RS12545 (KW115_12545) 2554962..2555474 - 513 WP_218806056.1 hypothetical protein -
KW115_RS12550 (KW115_12550) 2555575..2555877 - 303 WP_218806057.1 HigA family addiction module antitoxin Antitoxin
KW115_RS12555 (KW115_12555) 2555877..2556155 - 279 WP_218806058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW115_RS12560 (KW115_12560) 2556195..2557313 - 1119 WP_218806059.1 tyrosine-type recombinase/integrase -
KW115_RS12570 (KW115_12570) 2558261..2558650 + 390 WP_218806060.1 exosortase system-associated protein, TIGR04073 family -
KW115_RS12575 (KW115_12575) 2558927..2560849 - 1923 WP_218806061.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10546.73 Da        Isoelectric Point: 7.5217

>T209221 WP_218806058.1 NZ_CP079095:c2556155-2555877 [Methylococcus sp. Mc7]
MIQSFKHKGLSRYFAEDDHRGINPKQAARIRRLLDRLDAAAQAEDMNLPGYGFHGLAHNRAGEYAVTVSGNWRITFRFES
GHAFDVNLEDYH

Download         Length: 279 bp

>T209221 NZ_CP103972:c1781530-1781123 [Escherichia coli]
GTGGTTCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11324.11 Da        Isoelectric Point: 10.0757

>AT209221 WP_218806057.1 NZ_CP079095:c2555877-2555575 [Methylococcus sp. Mc7]
MKSLRHDRRRPTHPGEVLREDVLPALGITQTELAKRLMVSRVTVSEILLEKRALSPDMAVRISRLTSTTPESWLAMQQAV
DLWEVNQHPERYAAISPVAA

Download         Length: 303 bp

>AT209221 NZ_CP103972:c1781777-1781511 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTTCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References