Detailed information of TA system TA209211

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2444387..2444571
• Replicon: chromosome
• Accession: NZ_CP078521
• Organism: Staphylococcus aureus strain ATCC 29213

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KWH15_RS12230
• Protein ID: WP_000482652.1
• Coordinates: 2444464..2444571 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2444387..2444447 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWH15_RS12215	2439842..2439973	-	132	WP_223197975.1	hypothetical protein	-
KWH15_RS12220	2440240..2441973	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
KWH15_RS12225	2441998..2443761	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2444387..2444447	+	61	-	-	Antitoxin
KWH15_RS12230	2444464..2444571	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
KWH15_RS12235	2444705..2445091	-	387	WP_000779360.1	flippase GtxA	-
KWH15_RS12240	2445359..2446501	+	1143	WP_001176863.1	glycerate kinase	-
KWH15_RS12245	2446561..2447220	+	660	WP_000831298.1	membrane protein	-
KWH15_RS12250	2447402..2448613	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KWH15_RS12255	2448736..2449209	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T209211 WP_000482652.1 NZ_CP078521:c2444571-2444464 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T209211 NZ_CP103965:1803553-1803765 [Pseudomonas sp. N3-W]
GTGCAGAGCAGGCTATTGATGAAGGAGTTGATGGAGGCAGGCTGGACGCTGGATCGGGTCACCGGCAGTCATCACATCTT
CACCCATCGTTACAACCCGTACACGATTCCCGTCCCGCACCCGAAAAAGGATTTGCCGTTCGGGACGGTCAAGAGCATCA
GGAGGCGCGCCGGGCTCTATTGCCCGCCGGCCAGTTACGCAGGAGATCCATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT209211 NZ_CP078521:2444387-2444447 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin