Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2418886..2419403 | Replicon | chromosome |
| Accession | NZ_CP078521 | ||
| Organism | Staphylococcus aureus strain ATCC 29213 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | KWH15_RS12095 | Protein ID | WP_000113265.1 |
| Coordinates | 2418886..2419152 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KWH15_RS12100 | Protein ID | WP_000584499.1 |
| Coordinates | 2419152..2419403 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWH15_RS12065 (2414314) | 2414314..2414850 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KWH15_RS12070 (2415084) | 2415084..2415908 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| KWH15_RS12075 (2416125) | 2416125..2416307 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| KWH15_RS12080 (2416391) | 2416391..2416858 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| KWH15_RS12085 (2417044) | 2417044..2418591 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KWH15_RS12090 (2418780) | 2418780..2418851 | - | 72 | Protein_2340 | hypothetical protein | - |
| KWH15_RS12095 (2418886) | 2418886..2419152 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| KWH15_RS12100 (2419152) | 2419152..2419403 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KWH15_RS12105 (2419568) | 2419568..2419648 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| KWH15_RS12110 (2419676) | 2419676..2420275 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| KWH15_RS12115 (2420294) | 2420294..2420656 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KWH15_RS12120 (2420911) | 2420911..2422161 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| KWH15_RS12125 (2422258) | 2422258..2422989 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KWH15_RS12130 (2422986) | 2422986..2423705 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T209210 WP_000113265.1 NZ_CP078521:c2419152-2418886 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T209210 NZ_CP103965:c1802800-1802225 [Pseudomonas sp. N3-W]
GTGAGGCATTCCCCGTTTACCGCTGTATATGACGCTTGCGTGCTGTACCCCGCCCCTTTGAGAGACTTCCTGATGTGGCT
TGCGCTCTCAGGGCGTTTCAGGGCGAAATGGTCTGAGGAAATACACAACGAATGGAAACGAAATCTGCTGAAAAACCGCC
CTGACCTGATGCCTGAACAGCTGGACCGCACATCCGGACTGATGGAACAGGCGATACCCGATGCTTGTGTATACGGTTAT
GAAGCGCTGATTGATGGGCTGGTGCTGCCGGATGTCGATGACCGACATGTTCTGGCAGTTGCCATCCGCTGCAATGCCAG
TGTCATCGTCACGTTCAATCAGAAAGACTTTCCCTGCGCTGTGCTACGACCTTATGGCATTGAGGCTCAGCACCCAGATG
AGTTTGTCGATAATCTCATGGACCTCGATCCGGCCGCGGTGATTGCGGCGGCCCAACGGCAACGCCAGCAGCTGAAGATG
CCGCCAATGGATGTCAGCGCTTACCTCAATCTGTTACTGCGTCAGGGCTTGGTACAATCGAGCAAGGCTTTAACCCTTTA
TCAGGCGATTCTCTGA
GTGAGGCATTCCCCGTTTACCGCTGTATATGACGCTTGCGTGCTGTACCCCGCCCCTTTGAGAGACTTCCTGATGTGGCT
TGCGCTCTCAGGGCGTTTCAGGGCGAAATGGTCTGAGGAAATACACAACGAATGGAAACGAAATCTGCTGAAAAACCGCC
CTGACCTGATGCCTGAACAGCTGGACCGCACATCCGGACTGATGGAACAGGCGATACCCGATGCTTGTGTATACGGTTAT
GAAGCGCTGATTGATGGGCTGGTGCTGCCGGATGTCGATGACCGACATGTTCTGGCAGTTGCCATCCGCTGCAATGCCAG
TGTCATCGTCACGTTCAATCAGAAAGACTTTCCCTGCGCTGTGCTACGACCTTATGGCATTGAGGCTCAGCACCCAGATG
AGTTTGTCGATAATCTCATGGACCTCGATCCGGCCGCGGTGATTGCGGCGGCCCAACGGCAACGCCAGCAGCTGAAGATG
CCGCCAATGGATGTCAGCGCTTACCTCAATCTGTTACTGCGTCAGGGCTTGGTACAATCGAGCAAGGCTTTAACCCTTTA
TCAGGCGATTCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT209210 WP_000584499.1 NZ_CP078521:c2419403-2419152 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT209210 NZ_CP103965:c1803264-1802797 [Pseudomonas sp. N3-W]
ATGTCGCCAGTTATCCATTCCCCCCTCACTTTGCCCATAGAGCGCGAAGTTCAGGCTGCTATCGAAGGGCAACGCACGCT
TGCTGCGTGGCTGGCCACCCGATTCGAAACTCAACAGATCCAGATTTTCGACGAACAGAACAAGGCTCACAGCGTCGAAC
TGCCAACCTCGGCACTTCGGCTGCTGGTCGACATTCTGGCTGAGCTCGCCGCGGGCAACGCTGTCAAAGTGGTTCCGGTT
CATGCAGAGCTGACTACCCAGGAAGCGGCAGACTTGCTCAACGTCTCACGCCCGCATCTGATCAAGCTGCTGGAATCTGG
CGATTTGTCCTACCACAAAACCGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGACTATAAAAACCGGCGCGACA
CCGCCAGCGAGCGAGCAATGACGCTTCTCGCCGAACAAGCACAGGCGTTAAGGACAGGATACGAGTGA
ATGTCGCCAGTTATCCATTCCCCCCTCACTTTGCCCATAGAGCGCGAAGTTCAGGCTGCTATCGAAGGGCAACGCACGCT
TGCTGCGTGGCTGGCCACCCGATTCGAAACTCAACAGATCCAGATTTTCGACGAACAGAACAAGGCTCACAGCGTCGAAC
TGCCAACCTCGGCACTTCGGCTGCTGGTCGACATTCTGGCTGAGCTCGCCGCGGGCAACGCTGTCAAAGTGGTTCCGGTT
CATGCAGAGCTGACTACCCAGGAAGCGGCAGACTTGCTCAACGTCTCACGCCCGCATCTGATCAAGCTGCTGGAATCTGG
CGATTTGTCCTACCACAAAACCGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGACTATAAAAACCGGCGCGACA
CCGCCAGCGAGCGAGCAATGACGCTTCTCGCCGAACAAGCACAGGCGTTAAGGACAGGATACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|