Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 12315..12817 Replicon plasmid pEG002
Accession NZ_CP078507
Organism Enterococcus gallinarum strain fecal_iso1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KW861_RS16945 Protein ID WP_103301125.1
Coordinates 12315..12581 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KW861_RS16950 Protein ID WP_103301126.1
Coordinates 12566..12817 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW861_RS16905 (KW861_16880) 8090..8449 - 360 WP_176333683.1 hypothetical protein -
KW861_RS16910 (KW861_16885) 8626..8724 + 99 WP_146035423.1 type I toxin-antitoxin system Fst family toxin -
KW861_RS16915 (KW861_16895) 9236..9529 + 294 WP_228073928.1 SOS response-associated peptidase family protein -
KW861_RS16920 (KW861_16900) 9757..9855 - 99 WP_138372344.1 type I toxin-antitoxin system Fst family toxin -
KW861_RS16925 (KW861_16905) 10234..10941 + 708 WP_103301122.1 ParA family protein -
KW861_RS16930 (KW861_16910) 10941..11270 + 330 WP_103301123.1 hypothetical protein -
KW861_RS16935 (KW861_16915) 11668..11838 - 171 WP_167757216.1 hypothetical protein -
KW861_RS16940 (KW861_16920) 11998..12225 - 228 WP_103301124.1 hypothetical protein -
KW861_RS16945 (KW861_16925) 12315..12581 - 267 WP_103301125.1 Txe/YoeB family addiction module toxin Toxin
KW861_RS16950 (KW861_16930) 12566..12817 - 252 WP_103301126.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KW861_RS16955 (KW861_16935) 13036..13638 + 603 WP_103301127.1 recombinase family protein -
KW861_RS16960 (KW861_16940) 13722..13817 + 96 WP_140444174.1 type I toxin-antitoxin system Fst family toxin -
KW861_RS16965 (KW861_16945) 14195..14857 - 663 WP_103301128.1 super-infection exclusion protein B -
KW861_RS16970 (KW861_16950) 14894..15469 - 576 WP_103301129.1 recombinase family protein -
KW861_RS16975 (KW861_16955) 15485..16090 - 606 WP_103301130.1 Fic family protein -
KW861_RS16980 (KW861_16960) 16860..17495 + 636 WP_103301131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93444 93444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10368.07 Da        Isoelectric Point: 10.2555

>T209190 WP_103301125.1 NZ_CP078507:c12581-12315 [Enterococcus gallinarum]
MGYNVKIKKNARKDLPKLKSVNLTSKFDELIKVIKENPFQTPSPYENLTGLPYYSRRLNIKHRLVYSVDEESKTITILSV
WLHYERGL

Download         Length: 267 bp

>T209190 NZ_CP103895:378918-379337 [Corynebacterium diphtheriae bv. mitis]
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9496.57 Da        Isoelectric Point: 4.0940

>AT209190 WP_103301126.1 NZ_CP078507:c12817-12566 [Enterococcus gallinarum]
MEVITPTNARKNLYGIIKHVVSDSQPIEIASTKDEESVIMVSKSDWNSLQETIYLQNAGVLDRIKHFENEESEDLGEIDW
DTM

Download         Length: 252 bp

>AT209190 NZ_CP103895:378307-378873 [Corynebacterium diphtheriae bv. mitis]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References