Detailed information of TA system TA209184

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2561966..2562303
• Replicon: chromosome
• Accession: NZ_CP078162
• Organism: Enterococcus faecalis strain NS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: KVY10_RS12070
• Protein ID: WP_002396786.1
• Coordinates: 2561966..2562109 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2562041..2562303 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY10_RS12050	2558124..2558762	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
KVY10_RS12055	2559449..2561065	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
KVY10_RS12060	2561297..2561479	+	183	WP_002424907.1	type I toxin-antitoxin system toxin PepG1	-
KVY10_RS12065	2561598..2561738	+	141	WP_073340360.1	putative holin-like toxin	-
KVY10_RS12070	2561966..2562109	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2562041..2562303	-	263	-	-	Antitoxin
KVY10_RS12075	2562304..2566995	-	4692	WP_218391326.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T209184 WP_002396786.1 NZ_CP078162:2561966-2562109 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T209184 NZ_CP103891:127366-127629 [Corynebacterium diphtheriae bv. mitis]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGTCTACGACTAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT209184 NZ_CP078162:c2562303-2562041 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin